Chung Jin D, Porrello Enzo R, Lynch Gordon S
Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, 3010, VIC, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, 3052, VIC, Australia; Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, 3052, VIC, Australia.
Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, 3010, VIC, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, 3052, VIC, Australia; Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, 3052, VIC, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, 3010, VIC, Australia.
Free Radic Biol Med. 2025 Feb 1;227:52-63. doi: 10.1016/j.freeradbiomed.2024.11.041. Epub 2024 Nov 22.
Skeletal muscle has a high regenerative capacity due to its resident adult muscle stem cells (MuSCs), which can repair damaged tissue by forming myofibres de novo. Stem cell dependent regeneration is critical for maintaining skeletal muscle health, and different conditions can draw heavily on MuSC support to preserve muscle function, including metabolic diseases such as diabetes. The global incidence and burden of diabetes is increasing, and skeletal muscle is critical for maintaining systemic metabolic homeostasis and improving outcomes for diabetic patients. Thus, poor muscle health in diabetes, termed diabetic myopathy, is an important complication that must be addressed. The health of MuSCs is also affected by diabetes, responsible for the poor muscle regenerative capacity and contributing to the functional decline in diabetic patients. Here, we review the impact of diabetes and metabolic disease on MuSCs and skeletal muscle, including potential mechanisms for impaired muscle regeneration and MuSC dysfunction, and how these deficits could be addressed.
由于其驻留的成体肌肉干细胞（MuSCs），骨骼肌具有很高的再生能力，这些干细胞可以通过重新形成肌纤维来修复受损组织。依赖干细胞的再生对于维持骨骼肌健康至关重要，不同的情况可能严重依赖MuSC的支持来维持肌肉功能，包括糖尿病等代谢性疾病。全球糖尿病的发病率和负担正在增加，骨骼肌对于维持全身代谢稳态和改善糖尿病患者的预后至关重要。因此，糖尿病患者肌肉健康不佳，即糖尿病性肌病，是一个必须解决的重要并发症。MuSCs的健康也受到糖尿病的影响，导致肌肉再生能力差，并导致糖尿病患者的功能衰退。在这里，我们综述了糖尿病和代谢性疾病对MuSCs和骨骼肌的影响，包括肌肉再生受损和MuSC功能障碍的潜在机制，以及如何解决这些缺陷。
