Sabel K G, Wadsworth C
Acta Paediatr Scand. 1979 Nov;68(6):825-31. doi: 10.1111/j.1651-2227.1979.tb08219.x.
The usefulness of CRP in early detection of neonatal septicemia/meningitis and urinary tract infection was studied in a neonatal unit using a semiquantitative latex-agglutination as a rapid screening method, and electroimmuno assay as reference method for CRP determination. In 94% of non-infected infants CRP was less than or equal to 15 mg/l and 82% had CRP less than 10 mg/l up to 3 days of age. After 3 days of age 96% had CRP less than 10 mg/l. The initial CRP level was increased in 16 out of 18 patients (89%) with bacterial septicemia. Low CRP was seen in one patient with total agranulocytosis and septicemia from Streptococcus type B and in one patient with Staphylococcus albus sepsis. A rise in CRP was also seen in very pre-term infants with septicemia. Increased initial CRP was uncommon in neonatal urinary tract infection (2 of 9), but a rise was seen in 3 additional patients. A comparison between CRP, total neutrophil blood cell count and band neutrophil count as diagnostic parameters was in favour of CRP at this early stage of infection. CRP is of definite value as an aid in early diagnosis of neonatal septicemia and bacterial meningitis.
在一家新生儿病房，使用半定量乳胶凝集法作为快速筛查方法，并以电免疫分析法作为测定CRP的参考方法，研究了CRP在新生儿败血症/脑膜炎和尿路感染早期检测中的作用。在94%的未感染婴儿中，CRP小于或等于15mg/L，在出生3天内，82%的婴儿CRP小于10mg/L。3天后，96%的婴儿CRP小于10mg/L。18例细菌性败血症患者中有16例（89%）初始CRP水平升高。1例全粒细胞缺乏症合并B型链球菌败血症患者和1例白色葡萄球菌败血症患者CRP水平较低。败血症的极早产儿也出现CRP升高。新生儿尿路感染时初始CRP升高并不常见（9例中有2例），但另外3例患者出现CRP升高。在感染早期，将CRP、总中性粒细胞血细胞计数和带状中性粒细胞计数作为诊断参数进行比较，CRP更具优势。CRP在新生儿败血症和细菌性脑膜炎的早期诊断中具有一定价值。
