Sharma Ashish, Gokkulakrishnan Sadhasivam, Shahi Ashish Kumar, Kumar Vijay
Department of OMFS, Kothiwal Dental College and Research Centre, Moradabad, India.
Natl J Maxillofac Surg. 2012 Jul;3(2):148-51. doi: 10.4103/0975-5950.111369.
Study included 20 patients with diagnosis of fascial space infections of odontogenic origin to assess efficacy of serum CRP levels as monitoring tools for determining severity of infections, hospital stay and efficacy of treatment.
Blood samples taken on Day 0, 4 and 8 for measuring serum levels of marker. Simultaneously clinical parameters like swelling size, pain etc. were also recorded on Day 0, 4 and 8 and appropriate treatment given to each patient. Correlation between markers and parameters was found using regression and paired t-test.
Statistical analysis found strong correlation between lab. values of markes and parameters used to measure severity of infection. Also CRP is significant marker for hospital stay (P<.01).
Prospective analysis indicates CRP can be effective marker for determining severity of infection, treatment efficacy and hospital stay. Duration of antibiotic usage, intensive unit care, use of nutritional supplements becomes more rationale. Markers also make treatment cost effective and help protecting patients from side effects of excess drug usage.
该研究纳入了20例诊断为牙源性筋膜间隙感染的患者，以评估血清CRP水平作为监测感染严重程度、住院时间和治疗效果的工具的有效性。
在第0天、第4天和第8天采集血样以测定标志物的血清水平。同时，在第0天、第4天和第8天记录诸如肿胀大小、疼痛等临床参数，并给予每位患者适当的治疗。使用回归分析和配对t检验来寻找标志物与参数之间的相关性。
统计分析发现标志物的实验室值与用于测量感染严重程度的参数之间存在强相关性。此外，CRP是住院时间的重要标志物（P<0.01）。
前瞻性分析表明，CRP可作为确定感染严重程度、治疗效果和住院时间的有效标志物。抗生素使用时间、重症监护病房护理、营养补充剂的使用变得更具合理性。标志物还使治疗具有成本效益，并有助于保护患者免受过度用药的副作用。
