Health Science Research, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
Paediatrics & Paediatric Cardiology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India
BMJ Paediatr Open. 2024 Nov 24;8(1):e002955. doi: 10.1136/bmjpo-2024-002955.
Neonatal sepsis, a significant contributor to global neonatal mortality, poses substantial risks to infant health, particularly in low-resource countries like Nepal. Despite its high prevalence, there is a lack of clarity in defining and understanding neonatal sepsis, leading to challenges in diagnosing and managing the condition effectively. The probable impact of neonatal sepsis on long-term neurodevelopmental outcomes, including motor and cognitive delays, remains under-explored in Nepal. The primary objective of this study is to report the prevalence of neurodevelopmental delay in neonates with documented sepsis. The secondary objective is to report significant associations of the same with selected probable risk factors.
This is a dual-centric prospective cohort study that is ongoing at two hospitals-Paropakar Maternity and Women's Hospital and Siddhi Memorial Hospital in Nepal, over a 2-year period. Neonates diagnosed with sepsis will be assessed using the Developmental Assessment Scale for Indian Infants at 6 months and 1 year, postdiagnosis. Statistical analyses will include prevalence estimation and logistic regression.
新生儿败血症是全球新生儿死亡的主要原因之一，对婴儿健康构成重大威胁，特别是在尼泊尔等资源匮乏的国家。尽管新生儿败血症的患病率很高，但在定义和理解新生儿败血症方面仍存在不明确之处，导致有效诊断和治疗该病存在挑战。新生儿败血症对长期神经发育结局（包括运动和认知延迟）的可能影响在尼泊尔尚未得到充分探索。本研究的主要目的是报告有记录的败血症新生儿的神经发育延迟患病率。次要目标是报告这些与选定的可能危险因素的显著关联。
这是一项为期两年的在尼泊尔 Paropakar 妇产医院和 Siddhi Memorial 医院进行的双中心前瞻性队列研究。在诊断为败血症后，将使用印度婴儿发育评估量表对新生儿进行 6 个月和 1 岁时的评估。统计分析将包括患病率估计和逻辑回归。
