Division of Health Sciences and Nursing, Department of Midwifery and Women's Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Jpn J Nurs Sci. 2025 Jan;22(1):e12631. doi: 10.1111/jjns.12631.
To determine the effect of maternal egg consumption during lactation on the development of egg allergies in 12-month-old infants. We hypothesized that infants whose mothers consume larger amounts of eggs during the early lactation period acquire oral immune tolerance and are less likely to develop egg allergies at 12 months.
This study was a part of the Japan Pregnancy Eating and Activity Cohort Study. Mothers answered questionnaires on egg consumption, breastfeeding rates at 1 month, infants' eczema at 6 months, and the development of egg allergies among infants at 12 months. In order to assess the actual impact of maternal egg consumption on infants' egg allergy development, breastfeeding-dependent egg consumption was calculated at 1 month by multiplying maternal egg consumption at 1 month with the breastfeeding rates at the same time. Logistic regression analysis was performed to examine the potential risk and protective factors.
Data from 420 infants were analyzed, of whom 27 had egg allergies at 12 months. No significant impact of breastfeeding-dependent egg consumption was observed on infants' egg allergy development at 12 months. However, infants with eczema at 6 months showed a greater risk of developing an egg allergy at 12 months (adjusted odds ratio, 3.59; 95% confidence interval, 1.59-8.13).
The results suggest that breastfeeding-dependent egg consumption at 1 month did not contribute to sufficient oral immune tolerance in 12-month-old infants. Eczema at 6 months significantly impacted the development of an egg allergy, emphasizing the importance of preventing cutaneous exposure to egg allergens.
确定哺乳期母亲摄入鸡蛋的量对 12 月龄婴儿鸡蛋过敏发展的影响。我们假设，在哺乳期早期摄入较多鸡蛋的婴儿会获得口服免疫耐受，因此在 12 月龄时不太可能发生鸡蛋过敏。
本研究是日本妊娠饮食与活动队列研究的一部分。母亲们回答了关于鸡蛋摄入量、1 月龄母乳喂养率、6 月龄婴儿湿疹以及 12 月龄婴儿鸡蛋过敏发展情况的问卷。为了评估母亲鸡蛋摄入量对婴儿鸡蛋过敏发展的实际影响，通过将 1 月龄的母亲鸡蛋摄入量与同时的母乳喂养率相乘，计算了 1 月龄时依赖母乳喂养的鸡蛋摄入量。采用逻辑回归分析来检查潜在的风险和保护因素。
对 420 名婴儿的数据进行了分析，其中 27 名婴儿在 12 月龄时患有鸡蛋过敏。12 月龄时，依赖母乳喂养的鸡蛋摄入量对婴儿鸡蛋过敏发展无显著影响。然而，6 月龄时患有湿疹的婴儿在 12 月龄时发生鸡蛋过敏的风险更大（调整后的优势比，3.59；95%置信区间，1.59-8.13）。
结果表明，1 月龄时依赖母乳喂养的鸡蛋摄入量并未为 12 月龄婴儿提供足够的口服免疫耐受。6 月龄时的湿疹显著影响鸡蛋过敏的发展，强调了预防皮肤接触鸡蛋过敏原的重要性。
