Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Sci Rep. 2024 Nov 24;14(1):29104. doi: 10.1038/s41598-024-80659-w.
Functional capacity is an important objective health metric, and relies on the maintenance of physiological homeostasis. Autonomic nervous system is known to coordinates the maintenance of multi-organ homeostasis. The objective of this study was to examine the association of autonomic nervous system function with functional capacity in adults aged 55 years and older. A cohort of 542 adults (mean age of 70.1 years) received repeated measurements of heart rate variability, an autonomic nervous system function marker, and chair rise time, a functional capacity measure. Linear mixed models analysis showed that 1 SD lower powers in low-frequency range at baseline was associated with a 0.11 (95% CI 0.01-0.21) s/year faster increase in chair rise time during the follow-up, whereas 1 SD increase in powers in high-frequency range and 1 SD decrease in the ratio of powers in low-frequency range to powers in high-frequency range during the follow-up were associated with a 0.22 (95% CI 0.06-0.39) s and 0.17 (95% CI 0.01-0.33) s increase in chair rise time. In conclusion, autonomic nervous system function and its changes were longitudinally associated with changes in functional capacity in older adults.
功能能力是一个重要的客观健康指标，依赖于生理内稳态的维持。自主神经系统被认为协调多器官内稳态的维持。本研究的目的是探讨自主神经系统功能与 55 岁及以上成年人功能能力的关系。一个由 542 名成年人组成的队列（平均年龄为 70.1 岁）接受了心率变异性（自主神经系统功能标志物）和椅子上升时间（功能能力测量）的重复测量。线性混合模型分析显示，基线时低频范围的功率降低 1 个标准差与椅子上升时间在随访期间的增加速度加快 0.11 秒/年（95%CI 0.01-0.21）有关，而高频范围的功率增加 1 个标准差和低频范围的功率与高频范围的功率比在随访期间降低 1 个标准差与椅子上升时间增加 0.22 秒（95%CI 0.06-0.39）和 0.17 秒（95%CI 0.01-0.33）有关。总之，自主神经系统功能及其变化与老年人功能能力的变化具有纵向相关性。
