Zhang Manqi, Deng Mengjie, Li Xiaowen, Zhang Rui, Liao Jiejie, Peng Jun, Feng Huiyan, Tang Shixiong, Chen Yujie, Mo Lei
Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, People's Republic of China.
The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, People's Republic of China.
Soc Cogn Affect Neurosci. 2024 Dec 13;19(1). doi: 10.1093/scan/nsae086.
Research on the neuropathological mechanisms underlying minor depression (MD), particularly in individuals with a history of recurrent minor depressive episodes, is very limited. This study focuses on the abnormality in processing real-life emotional stimuli among individuals with MD. Thirty-two individuals with MD and 31 normal controls (NC) were recruited and underwent comprehensive clinical interview, cognitive assessment, and magnetic resonance imaging (MRI) scans. During functional MRI scanning, subjects watched positive, negative, and neutral emotional movie clips. We used the inter-subject correlation and inter-subject functional connectivity analysis to investigate the neural differentiation between MD and NC during film viewing. The relationships between neural differentiation, symptom severity, and psychological resilience were analysed. We found that neural differentiations between individuals with MD and NC in the post cingulate cortex (PCC) and precuneus (PCUN) were consistent across three emotional conditions. Notably, the similarity of neural responses in the PCC and PCUN with NC but not MD was negatively correlated with depressive symptoms. Furthermore, this neural similarity mediated the relationship between psychological resilience and depression severity. Our findings support that the PCC and PCUN, two core areas of the default mode network, play a critical role in MD's emotion processing deficit.
关于轻度抑郁症（MD）潜在神经病理机制的研究非常有限，尤其是在有复发性轻度抑郁发作史的个体中。本研究聚焦于MD患者对现实生活中情感刺激的处理异常。招募了32名MD患者和31名正常对照（NC），并对他们进行了全面的临床访谈、认知评估和磁共振成像（MRI）扫描。在功能MRI扫描期间，受试者观看了积极、消极和中性的情感电影片段。我们使用受试者间相关性和受试者间功能连接分析来研究MD患者和NC在观看电影期间的神经差异。分析了神经差异、症状严重程度和心理复原力之间的关系。我们发现，在三种情感条件下，MD患者和NC在扣带回后部（PCC）和楔前叶（PCUN）的神经差异是一致的。值得注意的是，PCC和PCUN中与NC而非MD的神经反应相似性与抑郁症状呈负相关。此外，这种神经相似性介导了心理复原力与抑郁严重程度之间的关系。我们的研究结果支持，默认模式网络的两个核心区域PCC和PCUN在MD的情绪处理缺陷中起关键作用。
