Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Neuroscience and Biomedical Engineering, and Advanced Magnetic Imaging Centre, Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland; Department of Psychology and Logopedics, Faculty of Medicine, Helsinki University, Helsinki, Finland.
Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Neuroscience and Biomedical Engineering, and Advanced Magnetic Imaging Centre, Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland; Department of Psychology and Logopedics, Faculty of Medicine, Helsinki University, Helsinki, Finland.
Schizophr Res. 2018 Sep;199:235-242. doi: 10.1016/j.schres.2018.03.018. Epub 2018 Mar 24.
Functional connectivity is altered in psychotic disorders. Multiple findings concentrate on the default mode network, anchored on the precuneus-posterior cingulate cortex (PC-PCC). However, the nature of the alterations varies between studies and connectivity alterations have not been studied during an ecologically valid natural stimulus. In the present study, we investigated the functional and structural connectivity of a PC-PCC region, where functioning differentiated first-episode psychosis patients from control subjects during free viewing of a movie in our earlier study.
14 first-episode psychosis patients and 12 control subjects were imaged with GE 3T, and 29 patients and 19 control subjects were imaged with a Siemens Skyra 3T scanner while watching scenes from the movie Alice in Wonderland. Group differences in functional connectivity were analysed for both scanners separately and results were compared to identify any overlap. Diffusion tensor measures of 26 patients and 19 control subjects were compared for the related white matter tracts, identified by deterministic tractography.
Functional connectivity was increased in patients across scanners between the midline regions of the PC-PCC and the anterior cingulate cortex-medial prefrontal cortex (ACC-mPFC). We found no group differences in any of the diffusion tensor imaging measures.
Already in the early stages of psychosis functional connectivity between the midline structures of the PC-PCC and the ACC-mPFC is consistently increased during naturalistic stimulus.
精神障碍患者的功能连接发生改变。多项研究集中于默认模式网络，该网络以楔前叶-后扣带回皮层（PC-PCC）为锚定点。然而，研究之间改变的性质有所不同，并且在生态有效自然刺激期间尚未研究连接改变。在本研究中，我们研究了 PC-PCC 区域的功能和结构连接，在我们之前的研究中，该区域的功能在首发精神病患者和对照组观看电影时将两者区分开来。
14 名首发精神病患者和 12 名对照组在 GE 3T 上进行成像，29 名患者和 19 名对照组在 Siemens Skyra 3T 扫描仪上观看电影《爱丽丝梦游仙境》的场景时进行成像。分别对两台扫描仪的功能连接进行组间差异分析，并比较结果以确定任何重叠。通过确定性追踪术比较了 26 名患者和 19 名对照组相关的白质束的弥散张量测量值。
在两台扫描仪上，患者的 PC-PCC 中线区域与前扣带皮层-内侧前额叶皮质（ACC-mPFC）之间的功能连接增加。我们在任何弥散张量成像测量中均未发现组间差异。
在精神病的早期阶段，PC-PCC 的中线结构与 ACC-mPFC 之间的功能连接在自然刺激期间持续增加。
