Deblier Ivo, Dossche Karl, Vanermen Anthony, Mistiaen Wilhelm
Department of Cardiovascular Surgery, ZNA Middelheim Hospital, Antwerp, Belgium.
Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp, Belgium.
Future Cardiol. 2024 Dec-Dec;20(15-16):849-858. doi: 10.1080/14796678.2024.2433827. Epub 2024 Nov 25.
Aortic valve replacement is the only effective treatment for symptomatic aortic valve disease. Transcatheter implantation has been introduced as alternative for surgery (SAVR), but its penetration varied widely. For high-risk octogenarian patients, the advantages of TAVI are clear. Patients between 75 and 79 years of age could be considered as "the gray zone."
We compared the outcome of SAVR with or without concomitant procedures between patients younger than 75 versus 75-79 years for their preoperative profile, operative parameters, and postoperative outcomes.
Older patients had a higher risk score with more cardiovascular comorbidity and renal dysfunction. They required more concomitant CABG but less mitral valve repair. Cardiopulmonary bypass time was similar. In-hospital complication rates, need for blood transfusion, and length of stay in intensive care unit were higher in older patients. Thirty-day mortality was not significantly increased, Euroscore II overestimated mortality in both age groups. Age over 75 years was not an independent predictor for mortality. Need for emergent SAVR was only predictive in the older group. Long-term survival was acceptable. Age over 75 years was not the dominant predictor.
SAVR remains a valid option to treat symptomatic aortic valve disease in the age group of 75-79.
主动脉瓣置换术是有症状的主动脉瓣疾病的唯一有效治疗方法。经导管植入术已作为外科手术(外科主动脉瓣置换术,SAVR)的替代方法被引入,但它的普及程度差异很大。对于高龄高危患者,经导管主动脉瓣植入术(TAVI)的优势很明显。75至79岁的患者可被视为“灰色地带”。
我们比较了年龄小于75岁与75至79岁患者行或不行同期手术的SAVR的术前情况、手术参数和术后结果。
老年患者风险评分更高,心血管合并症和肾功能不全更多。他们需要更多的同期冠状动脉旁路移植术(CABG),但二尖瓣修复较少。体外循环时间相似。老年患者的院内并发症发生率、输血需求和重症监护病房住院时间更高。30天死亡率没有显著增加,欧洲心脏手术风险评估系统(Euroscore)II高估了两个年龄组的死亡率。75岁以上并非死亡率的独立预测因素。急诊SAVR的需求仅在老年组中具有预测性。长期生存率尚可。75岁以上并非主要预测因素。
SAVR仍然是治疗75至79岁有症状主动脉瓣疾病的有效选择。