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Invasive pneumococcal disease among adults with hematological and solid organ malignancies: A population-based cohort study.成人血液系统和实体器官恶性肿瘤患者的侵袭性肺炎球菌病：一项基于人群的队列研究。
Int J Infect Dis. 2021 May;106:237-245. doi: 10.1016/j.ijid.2021.03.072. Epub 2021 Mar 26.
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Evaluation of the protein gap for detection of abnormal serum gammaglobulin level: an imperfect predictor.评估蛋白间隙以检测异常血清球蛋白水平：一个不完善的预测指标。
Clin Chem Lab Med. 2020 Nov 19;59(5):869-874. doi: 10.1515/cclm-2020-1286. Print 2021 Apr 27.
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Executive Summary of the Consensus Document on the Diagnosis and Management of Patients with Primary Immunodeficiencies.原发性免疫缺陷病患者诊断与管理共识文件摘要
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Nov;38(9):438-443. doi: 10.1016/j.eimc.2020.07.001.
5
Differences and Temporal Changes in Risk of Invasive Pneumococcal Disease in Adults with Hematological Malignancies: Results from a Nationwide 16-Year Cohort Study.血液恶性肿瘤患者侵袭性肺炎球菌病风险的差异及时间变化：一项全国性 16 年队列研究结果。
Clin Infect Dis. 2021 Feb 1;72(3):463-471. doi: 10.1093/cid/ciaa090.
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Prevalence of Hypogammaglobulinemia in Adult Invasive Pneumococcal Disease.成人侵袭性肺炎球菌病中低丙种球蛋白血症的患病率。
Clin Infect Dis. 2018 Feb 1;66(4):564-569. doi: 10.1093/cid/cix836.
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Diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection.青年期初次侵袭性细菌感染后原发性抗体和补体缺陷的诊断。
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8
Early mortality in multiple myeloma: Experiences from a single institution.
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9
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Long-term mortality in patients diagnosed with pneumococcal meningitis: a Danish nationwide cohort study.诊断为肺炎球菌性脑膜炎患者的长期死亡率：一项丹麦全国队列研究。
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侵袭性肺炎球菌病后低风险成人免疫功能低下状况的筛查：早期发现多发性骨髓瘤的契机

Searching for Immunocompromising Conditions in Low-risk Adults After Invasive Pneumococcal Disease: An Opportunity to Uncover Multiple Myeloma Early.

作者信息

Maestro de la Calle Guillermo, Mateo Flores Javier, Brañas Pilar, Viedma Esther, Lumbreras Bermejo Carlos

机构信息

Antimicrobial Stewardship Program, Hospital Universitario 12 de Octubre, Madrid, Spain.

Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.

出版信息

Open Forum Infect Dis. 2024 Nov 8;11(11):ofae653. doi: 10.1093/ofid/ofae653. eCollection 2024 Nov.

DOI:10.1093/ofid/ofae653
PMID:39582501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11584514/
Abstract

There is a paucity of data on the prevalence of newly diagnosed immunosuppressive conditions following a first invasive pneumococcal infection (IPI) in adults considered to be at low risk for it. A total of 352 IPIs were reviewed over a 7-year period, with 39 (11.1%) ultimately analyzed. A 3.4-year follow-up period revealed that 4 patients (10.3%) had been diagnosed with immunosuppressive conditions. Of these, 3 had been diagnosed with multiple myeloma (MM). These findings indicate that in adults who experience a first IPI and are at low risk for it, MM should be strongly considered and addressed as early as possible.

摘要

关于首次侵袭性肺炎球菌感染（IPI）后新诊断的免疫抑制性疾病在被认为低风险的成年人中的患病率，数据匮乏。在7年期间共审查了352例IPI，最终分析了39例（11.1%）。3.4年的随访期显示，4例患者（10.3%）被诊断患有免疫抑制性疾病。其中，3例被诊断为多发性骨髓瘤（MM）。这些发现表明，在经历首次IPI且风险较低的成年人中，应强烈考虑MM并尽早进行处理。