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肺炎链球菌促进肺癌的发生和发展。

Streptococcus pneumoniae promotes lung cancer development and progression.

作者信息

Li Ning, Zhou Huifen, Holden Van K, Deepak Janaki, Dhilipkannah Pushpa, Todd Nevins W, Stass Sanford A, Jiang Feng

机构信息

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

出版信息

iScience. 2023 Jan 4;26(2):105923. doi: 10.1016/j.isci.2022.105923. eCollection 2023 Feb 17.

DOI:10.1016/j.isci.2022.105923
PMID:36685035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9852931/
Abstract

is associated with lung cancer, yet its role in the tumorigenesis remains uncertain. Herein we find that attaches to lung cancer cells via binding pneumococcal surface protein C (PspC) to platelet-activating factor receptor (PAFR). Interaction between PspC and PAFR stimulates cell proliferation and activates PI3K/AKT and nuclear factor kB (NF-kB) signaling pathways, which trigger a pro-inflammatory response. Lung cancer cells infected with form larger tumors in BALB/C mice compared to untreated cells. Mice treated with tobacco carcinogen and develop more lung tumors and had shorter survival period than mice treated with the carcinogen alone. Mutating PspC or PAFR abolishes tumor-promoting effects of . Overabundance of is associated with the survival. may play a driving role in lung tumorigenesis by activating PI3K/AKT and NF-kB pathways via binding PspC to PAFR and provide a microbial target for diagnosis and treatment of the disease.

摘要

与肺癌相关，但其在肿瘤发生中的作用仍不确定。在此我们发现，通过结合肺炎球菌表面蛋白C（PspC）与血小板活化因子受体（PAFR）附着于肺癌细胞。PspC与PAFR之间的相互作用刺激细胞增殖并激活PI3K/AKT和核因子κB（NF-κB）信号通路，从而引发促炎反应。与未处理的细胞相比，感染的肺癌细胞在BALB/C小鼠中形成更大的肿瘤。用烟草致癌物和处理的小鼠比单独用致癌物处理的小鼠发生更多的肺肿瘤且生存期更短。突变PspC或PAFR可消除的促肿瘤作用。的过量与生存相关。可能通过将PspC与PAFR结合激活PI3K/AKT和NF-κB通路在肺肿瘤发生中起驱动作用，并为该疾病的诊断和治疗提供微生物靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/3fa30429ddc2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/8522bc25460d/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/17b5d500b869/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/7da612c073fa/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/4f472950611d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/a80f79fd8fd9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/2adf4b72942e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/3fa30429ddc2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/8522bc25460d/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/17b5d500b869/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/7da612c073fa/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/4f472950611d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/a80f79fd8fd9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/2adf4b72942e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c73/9852931/3fa30429ddc2/gr6.jpg

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[8]
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Front Immunol. 2025-7-24

[2]
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J Multidiscip Healthc. 2025-7-29

[3]
Shared blood gene signature in lung adenocarcinoma and microbial lung infections: a bioinformatic analysis and in silico validation.

Discov Oncol. 2025-7-24

[4]
DC-SIGN (CD209)-mediated interactions between bacteria, lung cancer tissues, and macrophages promote cancer metastasis.

Infect Agent Cancer. 2025-6-21

[5]
[Research Progress on the Relationship between Intratumor Microbiota and Lung Cancer].

Zhongguo Fei Ai Za Zhi. 2025-4-20

[6]
infection is associated with Matrix Metalloproteinase-9 in Lung Cancer Progression and Brain Metastases.

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[7]
Integrated network pharmacology, molecular docking, and animal experiments to reveal the potential mechanism of hesperetin on COPD.

Sci Rep. 2025-4-1

[8]
Decoding the Tumor-Associated Microbiota: From Origins to Nanomedicine Applications in Cancer Therapy.

Biology (Basel). 2025-2-27

[9]
Lung commensal bacteria promote lung cancer progression through NK cell-mediated immunosuppressive microenvironment.

Int J Med Sci. 2025-2-3

[10]
promotes synchronous multiple primary lung cancer progression through apoptosis regulation.

Front Immunol. 2025-1-9

本文引用的文献

[1]
Core Microbiota in Central Lung Cancer With Streptococcal Enrichment as a Possible Diagnostic Marker.

Arch Bronconeumol. 2021-11

[2]
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer.

Cell. 2022-4-14

[3]
High-Throughput Detection of Multiple miRNAs and Methylated DNA by Droplet Digital PCR.

J Pers Med. 2021-4-29

[4]
The microbiome and human cancer.

Science. 2021-3-26

[5]
Pathogenicity and virulence of : Cutting to the chase on proteases.

Virulence. 2021-12

[6]
Lower Airway Dysbiosis Affects Lung Cancer Progression.

Cancer Discov. 2021-2

[7]
A Non-Coding RNA Landscape of Bronchial Epitheliums of Lung Cancer Patients.

Biomedicines. 2020-4-13

[8]
Author Correction: Interaction between the microbiome and TP53 in human lung cancer.

Genome Biol. 2020-2-20

[9]
Studying the effects of several heat-inactivated bacteria on colon and breast cancer cells.

Mol Biol Res Commun. 2019-6

[10]
Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity.

Nat Microbiol. 2019-9-9

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