Faergemann J, Johansson S, Bäck O, Scheynius A
J Am Acad Dermatol. 1986 Mar;14(3):429-33. doi: 10.1016/s0190-9622(86)70053-4.
In patients with Pityrosporum folliculitis the mean serum antibody titer against Pityrosporum orbiculare was significantly higher than in healthy control subjects (p less than 0.01). The mean number of P. orbiculare organisms per square centimeter cultured from normal-looking skin in patients was not significantly higher than the number cultured from normal-looking skin in control subjects. Results of prick tests against P. orbiculare extract were negative or weak, indicating that patients with Pityrosporum folliculitis had no type I hypersensitivity against P. orbiculare. Immunohistochemical staining of skin lesions showed perivascular dermal cell infiltrates near the hair follicles dominated by anti-Leu 3a-reactive T lymphocytes. Human lymphocyte antigens with the DR locus, but not those with the DQ locus, on keratinocytes were observed in one case.
在糠秕孢子菌性毛囊炎患者中，针对圆形糠秕孢子菌的平均血清抗体滴度显著高于健康对照者（p<0.01）。患者外观正常皮肤每平方厘米培养出的圆形糠秕孢子菌数量并不显著高于对照者外观正常皮肤培养出的数量。针对圆形糠秕孢子菌提取物的点刺试验结果为阴性或弱阳性，表明糠秕孢子菌性毛囊炎患者对圆形糠秕孢子菌无Ⅰ型超敏反应。皮肤病变的免疫组织化学染色显示，毛囊周围真皮细胞浸润，以抗Leu 3a反应性T淋巴细胞为主。1例患者角质形成细胞上观察到具有DR位点的人类淋巴细胞抗原，但未观察到具有DQ位点的抗原。
