Lyon-Colbert Amber D, Basson Marc D, Klug Marilyn G, Schwartz Gary G
Department of Population Health, University of North Dakota, Grand Forks, ND 58202, United States.
College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, United States.
World J Clin Oncol. 2024 Nov 24;15(11):1454-1458. doi: 10.5306/wjco.v15.i11.1454.
This study aims to identify common contaminants in well water linked to an increase in colorectal cancer (CRC) incidence rates in North Dakota (ND) counties. County-specific incidence rates for CRC were obtained from the ND Statewide Cancer Registry. Corresponding demographic, agricultural, and geophysical data were obtained from population-based sources. Associations between well water contaminants and CRC incidence were examined for 16 counties in ND with complete well water profiles between 1997-2019. Data were analyzed by multiple linear regression. Iron in well water exhibited a significant positive association with CRC incidence (4.75, = 0.001), and barium exhibited a small, but significant negative association (-0.06907, = 0.01). Residents in counties in ND with prevalent well water usage contaminated with iron may be at higher risk for CRC.
本研究旨在确定与北达科他州（ND）各县结直肠癌（CRC）发病率上升相关的井水常见污染物。CRC的特定县发病率数据来自ND全州癌症登记处。相应的人口、农业和地球物理数据来自基于人群的来源。对ND州1997年至2019年间有完整井水概况的16个县，研究了井水污染物与CRC发病率之间的关联。数据通过多元线性回归进行分析。井水中的铁与CRC发病率呈显著正相关（4.75， = 0.001），钡则呈微弱但显著的负相关（-0.06907， = 0.01）。在ND州井水普遍受铁污染的县，居民患CRC的风险可能更高。
