Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Department of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Mol Aspects Med. 2020 Oct;75:100860. doi: 10.1016/j.mam.2020.100860. Epub 2020 Apr 25.
Iron plays an essential role in normal biological processes: The generation of cellular energy, oxygen transport, DNA synthesis and repair are all processes that require iron-coordinated proteins, either as elemental iron, heme or iron-sulfur clusters. As a transition metal with two major biological oxidation states, iron is also a critical intermediate in the generation of reactive oxygen species that can damage cellular structures and contribute to both aging and cancer. In this review, we focus on experimental and epidemiologic evidence that links iron and cancer, as well as strategies that have been proposed to either reduce or increase cellular iron for cancer therapy.
细胞能量的产生、氧气的运输、DNA 的合成和修复，所有这些过程都需要铁协调蛋白，无论是元素铁、血红素还是铁硫簇。作为一种具有两种主要生物氧化态的过渡金属，铁也是活性氧生成的关键中间体，活性氧可以破坏细胞结构，导致衰老和癌症。在这篇综述中，我们重点介绍了将铁与癌症联系起来的实验和流行病学证据，以及为癌症治疗而提出的减少或增加细胞铁的策略。
