Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.
Front Immunol. 2024 Nov 8;15:1481312. doi: 10.3389/fimmu.2024.1481312. eCollection 2024.
Obesity has emerged as a prominent global public health concern, leading to the development of numerous metabolic disorders such as cardiovascular diseases, type-2 diabetes mellitus (T2DM), sleep apnea and several system diseases. It is widely recognized that obesity is characterized by a state of inflammation, with immune cells-particularly macrophages-playing a significant role in its pathogenesis through the production of inflammatory cytokines and activation of corresponding pathways. In addition to their immune functions, macrophages have also been implicated in lipogenesis. Additionally, the mitochondrial disorders existed in macrophages commonly, leading to decreased heat production. Meantime, adipocytes have mitochondrial dysfunction and damage which affect thermogenesis and insulin resistance. Therefore, enhancing our comprehension of the role of macrophages and mitochondrial dysfunction in both macrophages and adipose tissue will facilitate the identification of potential therapeutic targets for addressing this condition.
肥胖已成为突出的全球公共卫生关注点，导致多种代谢紊乱的发生，如心血管疾病、2 型糖尿病（T2DM）、睡眠呼吸暂停和多种系统性疾病。人们普遍认识到，肥胖的特征是炎症状态，免疫细胞——特别是巨噬细胞——通过产生炎症细胞因子和激活相应途径，在其发病机制中发挥重要作用。除了免疫功能外，巨噬细胞还参与脂肪生成。此外，巨噬细胞中普遍存在线粒体紊乱，导致产热减少。同时，脂肪细胞也存在线粒体功能障碍和损伤，影响产热和胰岛素抵抗。因此，增强我们对巨噬细胞和线粒体功能障碍在巨噬细胞和脂肪组织中的作用的理解，将有助于确定解决这种情况的潜在治疗靶点。
