Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Immunol. 2024 Nov 8;15:1488913. doi: 10.3389/fimmu.2024.1488913. eCollection 2024.
Airways, alveoli and the pulmonary tissues are the most vulnerable to the external environment including occasional deliberate or accidental exposure to highly toxic chemical gases. However, there are many effective protective mechanisms that maintain the integrity of the pulmonary tissues and preserve lung function. Alveolar macrophages form the first line of defense against any pathogen or chemical/reactant that crosses the airway mucociliary barrier and reaches the alveolar region. Resident alveolar macrophages are activated or circulating monocytes infiltrate the airspace to contribute towards inflammatory or reparative responses. Studies on response of alveolar macrophages to noxious stimuli are rapidly emerging and alveolar macrophage are also being sought as therapeutic target. Here such studies have been reviewed and put together for a better understanding of the role pulmonary macrophages in general and alveolar macrophage in particular play in the pathogenesis of disease caused by chemical induced acute lung injury.
气道、肺泡和肺组织对外界环境最为敏感，包括偶尔故意或意外暴露于高毒性化学气体。然而，有许多有效的保护机制可以维持肺组织的完整性并保护肺功能。肺泡巨噬细胞是抵御任何穿过气道黏液纤毛屏障并到达肺泡区域的病原体或化学/反应物的第一道防线。常驻肺泡巨噬细胞被激活或循环单核细胞浸润到气腔中，以促进炎症或修复反应。关于肺泡巨噬细胞对有害刺激的反应的研究正在迅速涌现，并且肺泡巨噬细胞也被作为治疗靶点进行研究。在这里，我们综述了这些研究，以便更好地了解肺巨噬细胞，尤其是肺泡巨噬细胞在化学诱导性急性肺损伤引起的疾病发病机制中的作用。
