Kayani Kawan F, Ghafoor Dlzar, Mohammed Sewara J, Shatery Omer B A
Department of Chemistry, College of Science, Charmo University Peshawa Street, Chamchamal Sulaimani City 46023 Iraq.
Department of Chemistry, College of Science, University of Sulaimani Qliasan St Sulaimani City Kurdistan Region 46002 Iraq
Nanoscale Adv. 2024 Nov 22;7(1):42-59. doi: 10.1039/d4na00763h. eCollection 2024 Dec 17.
The disruption of glucose (Glu) metabolism in the human body can lead to conditions such as diabetes and hyperglycemia. Therefore, accurately determining Glu levels is crucial for clinical diagnosis and other applications. Carbon dots (CDs) are a novel category of carbon nanomaterials that exhibit outstanding optical properties, excellent biocompatibility, high water solubility, low production costs, and straightforward synthesis. Recently, researchers have developed various carbon dot sensors for fast and real-time Glu monitoring. In this context, we provide a comprehensive introduction to Glu and CDs for the first time. We categorize the synthetic methods for CDs and the sensing mechanisms, further classifying the applications of carbon dot probes into single-probe sensing, ratiometric sensing, and visual detection. Finally, we discuss the future development needs for CD-based Glu sensors. This review aims to offer insights into advancing Glu sensors and modern medical treatments.
人体中葡萄糖（Glu）代谢的紊乱会导致糖尿病和高血糖等病症。因此，准确测定Glu水平对于临床诊断和其他应用至关重要。碳点（CDs）是一类新型碳纳米材料，具有出色的光学性能、优异的生物相容性、高水溶性、低成本以及合成简便等特点。最近，研究人员开发了各种用于快速实时监测Glu的碳点传感器。在此背景下，我们首次对Glu和CDs进行全面介绍。我们对CDs的合成方法和传感机制进行了分类，进一步将碳点探针的应用分为单探针传感、比率传感和视觉检测。最后，我们讨论了基于CDs的Glu传感器未来的发展需求。本综述旨在为推进Glu传感器和现代医学治疗提供见解。
