• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Pegloticase-Induced Rapid Uric Acid Lowering and Kidney and Cardiac Health Markers in Youth-Onset Type 2 Diabetes: A Pilot Clinical Trial.

作者信息

Narongkiatikhun Phoom, Park Sungho, Rydin Amy, Rountree-Jablin Callie, Choi Ye Ji, Antenor Jo Ann, Pyle Laura, Driscoll Lynette, van Raalte Daniel, Pushea Maureen, Caldwell-McGee Alyssa, Ophascharoensuk Vuddhidej, Nadeau Kristen, Tommerdahl Kalie, Johnson Richard J, Browne Lorna, Barker Alex J, Bjornstad Petter

机构信息

Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, University of Washington School of Medicine, Seattle, WA.

Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

出版信息

Kidney Med. 2024 Oct 9;6(12):100911. doi: 10.1016/j.xkme.2024.100911. eCollection 2024 Dec.

DOI:10.1016/j.xkme.2024.100911
PMID:39583178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11582406/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e2/11582406/5a57abaf0683/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e2/11582406/5a57abaf0683/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e2/11582406/5a57abaf0683/gr1.jpg

相似文献

1
Pegloticase-Induced Rapid Uric Acid Lowering and Kidney and Cardiac Health Markers in Youth-Onset Type 2 Diabetes: A Pilot Clinical Trial.聚乙二醇化尿酸酶诱导青年起病2型糖尿病患者尿酸快速降低及肾脏和心脏健康标志物变化：一项试点临床试验
Kidney Med. 2024 Oct 9;6(12):100911. doi: 10.1016/j.xkme.2024.100911. eCollection 2024 Dec.
2
Pegloticase for chronic gout.聚乙二醇化尿酸酶用于慢性痛风。
Cochrane Database Syst Rev. 2010 Mar 17;2010(3):CD008335. doi: 10.1002/14651858.CD008335.pub2.
3
Interventions for tophi in gout.痛风石的治疗。
Cochrane Database Syst Rev. 2021 Aug 11;8(8):CD010069. doi: 10.1002/14651858.CD010069.pub3.
4
Prevention of kidney function decline using uric acid-lowering therapy in chronic kidney disease patients: a systematic review and network meta-analysis.降低慢性肾脏病患者尿酸水平的治疗对肾功能下降的预防作用：系统评价和网络荟萃分析。
Clin Rheumatol. 2022 Mar;41(3):911-919. doi: 10.1007/s10067-021-05956-5. Epub 2021 Oct 12.
5
Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study.尿酸与 1 型糖尿病青少年的心血管健康无关：青少年糖尿病研究中的搜索。
J Clin Endocrinol Metab. 2024 Jan 18;109(2):e726-e734. doi: 10.1210/clinem/dgad534.
6
Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease.用于预防或延缓慢性肾脏病进展的降尿酸疗法。
Cochrane Database Syst Rev. 2017 Oct 30;10(10):CD009460. doi: 10.1002/14651858.CD009460.pub2.
7
Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial.2型糖尿病青少年患者随机分组时及治疗反应中的胰岛素清除率：TODAY随机临床试验的二次分析
Diabetologia. 2025 Mar;68(3):676-687. doi: 10.1007/s00125-024-06327-w. Epub 2024 Dec 20.
8
Oral Urate-Lowering Therapy Use and Efficacy Following Pegloticase Treatment: Findings from a Rheumatology Network Database.聚乙二醇化尿酸酶治疗后口服降尿酸治疗的使用情况及疗效：来自风湿病学网络数据库的研究结果
Rheumatol Ther. 2025 Aug;12(4):709-719. doi: 10.1007/s40744-025-00767-5. Epub 2025 May 20.
9
Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients.用于治疗肾移植受者中已存在的和新发糖尿病的降糖药物。
Cochrane Database Syst Rev. 2017 Feb 27;2(2):CD009966. doi: 10.1002/14651858.CD009966.pub2.
10
Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis.降尿酸治疗对肾脏结局的影响：一项系统评价和荟萃分析。
Nephrol Dial Transplant. 2014 Feb;29(2):406-13. doi: 10.1093/ndt/gft378. Epub 2013 Sep 15.

引用本文的文献

1
The Hepatic Axis Fructose-Methylglyoxal-AMPK: Starring or Secondary Role in Chronic Metabolic Disease?肝脏轴中的果糖-甲基乙二醛-AMPK：在慢性代谢性疾病中是主角还是配角？
J Clin Med. 2025 May 19;14(10):3559. doi: 10.3390/jcm14103559.

本文引用的文献

1
Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial.CKD 患者中维立纳鲁与别嘌醇联合治疗的随机安慰剂和活性对照试验。
J Am Soc Nephrol. 2024 May 1;35(5):594-606. doi: 10.1681/ASN.0000000000000326. Epub 2024 Feb 20.
2
Effects of Allopurinol on the Progression of Chronic Kidney Disease.别嘌醇对慢性肾脏病进展的影响。
N Engl J Med. 2020 Jun 25;382(26):2504-2513. doi: 10.1056/NEJMoa1915833.
3
Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.
血清尿酸升高与肥胖 2 型糖尿病青少年发生高血压和糖尿病肾脏疾病的风险增加相关：来自青少年 2 型糖尿病治疗选择（TODAY）研究的观察性分析。
Diabetes Care. 2019 Jun;42(6):1120-1128. doi: 10.2337/dc18-2147. Epub 2019 Apr 9.
4
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.非布司他治疗 3 期 CKD 合并无症状高尿酸血症患者：一项随机试验。
Am J Kidney Dis. 2018 Dec;72(6):798-810. doi: 10.1053/j.ajkd.2018.06.028. Epub 2018 Sep 1.
5
Relationship between serum uric acid levels and intrarenal hemodynamic parameters.血清尿酸水平与肾内血流动力学参数之间的关系。
Kidney Blood Press Res. 2015;40(3):315-22. doi: 10.1159/000368507. Epub 2015 Jun 8.
6
Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects.肥胖人群血浆尿酸对其抗氧化能力、氧化应激及胰岛素敏感性的影响。
Diabetes. 2014 Mar;63(3):976-81. doi: 10.2337/db13-1396. Epub 2013 Dec 18.
7
Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL) allopurinol study.降低尿酸以预防糖尿病患者的肾功能丧失：预防早期肾功能丧失（PERL）别嘌醇研究。
Curr Diab Rep. 2013 Aug;13(4):550-9. doi: 10.1007/s11892-013-0381-0.
8
Uric acid: the oxidant-antioxidant paradox.尿酸：氧化-抗氧化悖论
Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):608-19. doi: 10.1080/15257770802138558.
9
Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout.聚乙二醇尿酸酶（pegloticase），一种尿酸酶的聚乙二醇共轭物，用于痛风的潜在静脉治疗。
Curr Opin Investig Drugs. 2008 Apr;9(4):422-9.