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放射性不对称输送器(REAC)神经再生(RGN-N)治疗对一名肾上腺脑白质营养不良患儿的功能恢复:详细病例报告

Functional Recovery in a Child With Adrenoleukodystrophy Following Neuroregenerative Effects of Radio Electric Asymmetric Conveyer (REAC) Neuro-Regenerative (RGN-N) Treatment: A Detailed Case Report.

作者信息

Rinaldi Salvatore, Rinaldi Arianna, Fontani Vania

机构信息

Research Department, Rinaldi Fontani Foundation, Florence, ITA.

Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, ITA.

出版信息

Cureus. 2024 Nov 23;16(11):e74283. doi: 10.7759/cureus.74283. eCollection 2024 Nov.

Abstract

This case report describes the treatment of a 9-year-old boy with advanced adrenoleukodystrophy (ALD) who received radioelectric asymmetric conveyer (REAC) neuro-regenerative (RGN-N) therapy after hematopoietic stem cell transplantation (HSCT) failed to produce therapeutic benefits. ALD is a devastating neurodegenerative disorder for which limited treatment options exist, and interventions are often ineffective in advanced cases. Post-transplant, the patient's symptoms worsened until REAC RGN-N therapy was introduced. After treatment, notable improvements were observed in motor function, swallowing, spasticity, and overall quality of life. These results suggest that REAC RGN-N treatment may be an effective intervention to slow neurodegenerative progression and support recovery in ALD cases unresponsive to HSCT.

摘要

本病例报告描述了一名患有晚期肾上腺脑白质营养不良(ALD)的9岁男孩的治疗情况。该男孩在造血干细胞移植(HSCT)未能产生治疗效果后,接受了射频不对称输送(REAC)神经再生(RGN-N)疗法。ALD是一种毁灭性的神经退行性疾病,治疗选择有限,在晚期病例中干预措施往往无效。移植后,患者症状恶化,直至引入REAC RGN-N疗法。治疗后,观察到运动功能、吞咽、痉挛和整体生活质量有显著改善。这些结果表明,REAC RGN-N治疗可能是一种有效的干预措施,可减缓神经退行性进展,并支持对HSCT无反应的ALD病例的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f5f/11585382/cad07bbd0e2a/cureus-0016-00000074283-i01.jpg

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