Rinaldi Salvatore, Rinaldi Arianna, Fontani Vania
Research Department, Rinaldi Fontani Foundation, Florence, ITA.
Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, ITA.
Cureus. 2024 Nov 23;16(11):e74283. doi: 10.7759/cureus.74283. eCollection 2024 Nov.
This case report describes the treatment of a 9-year-old boy with advanced adrenoleukodystrophy (ALD) who received radioelectric asymmetric conveyer (REAC) neuro-regenerative (RGN-N) therapy after hematopoietic stem cell transplantation (HSCT) failed to produce therapeutic benefits. ALD is a devastating neurodegenerative disorder for which limited treatment options exist, and interventions are often ineffective in advanced cases. Post-transplant, the patient's symptoms worsened until REAC RGN-N therapy was introduced. After treatment, notable improvements were observed in motor function, swallowing, spasticity, and overall quality of life. These results suggest that REAC RGN-N treatment may be an effective intervention to slow neurodegenerative progression and support recovery in ALD cases unresponsive to HSCT.
本病例报告描述了一名患有晚期肾上腺脑白质营养不良（ALD）的9岁男孩的治疗情况。该男孩在造血干细胞移植（HSCT）未能产生治疗效果后，接受了射频不对称输送（REAC）神经再生（RGN-N）疗法。ALD是一种毁灭性的神经退行性疾病，治疗选择有限，在晚期病例中干预措施往往无效。移植后，患者症状恶化，直至引入REAC RGN-N疗法。治疗后，观察到运动功能、吞咽、痉挛和整体生活质量有显著改善。这些结果表明，REAC RGN-N治疗可能是一种有效的干预措施，可减缓神经退行性进展，并支持对HSCT无反应的ALD病例的恢复。
