• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

弗雷明汉心脏研究后代队列中衰老表观遗传时钟的速度与认知衰退率的关联。

Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort.

作者信息

Savin Micah J, Wang Haoyang, Pei Heming, Aiello Allison E, Assuras Stephanie, Caspi Avshalom, Moffitt Terrie E, Muenning Peter A, Ryan Calen P, Shi Baoyi, Stern Yaakov, Sugden Karen, Valeri Linda, Belsky Daniel W

机构信息

Robert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USA.

Department of Biostatistics MSPH Columbia University Irving Medical Center New York New York USA.

出版信息

Alzheimers Dement (Amst). 2024 Nov 23;16(4):e70038. doi: 10.1002/dad2.70038. eCollection 2024 Oct-Dec.

DOI:10.1002/dad2.70038
PMID:39583644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11585167/
Abstract

INTRODUCTION

The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline.

METHODS

We analyzed Framingham Heart Study Offspring Cohort data ( = 2296; 46% male; baseline age = 62, SD = 9, range = 25-101 y). We measured cognitive decline across two decades of neuropsychological-testing follow-up. We measured pace of aging using the DunedinPACE epigenetic clock. Analysis tested if participants with faster DunedinPACE values experienced more rapid cognitive decline compared with those with slower DunedinPACE values.

RESULTS

Participants with faster DunedinPACE had poorer cognitive functioning at baseline and experienced more rapid cognitive decline over follow-up. Results were robust to confounders and consistent across population strata. Findings were similar for the PhenoAge and GrimAge epigenetic clocks.

DISCUSSION

Faster pace of aging is a risk factor for preclinical cognitive decline. Metrics of biological aging may inform risk stratification in clinical trials and prognosis in patient care.

HIGHLIGHTS

Faster DunedinPACE is associated with preclinical cognitive aging.Higher baseline cognition was protective of DunedinPACE-associated cognitive decline.The DunedinPACE association with cognitive decline explained a fourth of dementia risk.

摘要

引言

老年科学假说提出，系统性生物衰老为认知衰退的根本原因。

方法

我们分析了弗雷明汉心脏研究后代队列数据（n = 2296；46%为男性；基线年龄 = 62岁，标准差 = 9，范围 = 25 - 101岁）。我们在长达二十年的神经心理学测试随访中测量了认知衰退情况。我们使用达尼丁PACE表观遗传时钟来测量衰老速度。分析测试了与达尼丁PACE值较慢的参与者相比，达尼丁PACE值较快的参与者是否经历了更快的认知衰退。

结果

达尼丁PACE值较快的参与者在基线时认知功能较差，且在随访期间经历了更快的认知衰退。结果不受混杂因素影响，且在各人群分层中保持一致。对于PhenoAge和GrimAge表观遗传时钟，研究结果相似。

讨论

衰老速度较快是临床前认知衰退的一个风险因素。生物衰老指标可能为临床试验中的风险分层及患者护理中的预后提供信息。

要点

达尼丁PACE值较快与临床前认知衰老相关。较高的基线认知对达尼丁PACE相关的认知衰退具有保护作用。达尼丁PACE与认知衰退的关联解释了四分之一的痴呆风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e396/11585167/b03a78165b33/DAD2-16-e70038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e396/11585167/b50f3a79ee4e/DAD2-16-e70038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e396/11585167/b03a78165b33/DAD2-16-e70038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e396/11585167/b50f3a79ee4e/DAD2-16-e70038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e396/11585167/b03a78165b33/DAD2-16-e70038-g002.jpg

相似文献

1
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort.弗雷明汉心脏研究后代队列中衰老表观遗传时钟的速度与认知衰退率的关联。
Alzheimers Dement (Amst). 2024 Nov 23;16(4):e70038. doi: 10.1002/dad2.70038. eCollection 2024 Oct-Dec.
2
Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia.基于血液 DNA 甲基化的衰老速度与年龄相关性认知障碍和痴呆的关联。
Neurology. 2022 Sep 27;99(13):e1402-e1413. doi: 10.1212/WNL.0000000000200898. Epub 2022 Jul 6.
3
Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study.弗雷明汉心脏研究中的饮食、生物衰老速度与痴呆风险
medRxiv. 2023 May 29:2023.05.24.23290474. doi: 10.1101/2023.05.24.23290474.
4
A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts.体内加速衰老的血液生物标志物与大脑结构完整性较差相关：在三个队列中的重复验证
medRxiv. 2023 Sep 8:2023.09.06.23295140. doi: 10.1101/2023.09.06.23295140.
5
A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts.衰老速度的血液生物标志物与大脑结构有关：三个队列的复制结果。
Neurobiol Aging. 2024 Apr;136:23-33. doi: 10.1016/j.neurobiolaging.2024.01.008. Epub 2024 Jan 24.
6
DunedinPACE, a DNA methylation biomarker of the pace of aging.多恩比恩衰老速度预测指标（DunedinPACE），一种衰老速度的 DNA 甲基化生物标志物。
Elife. 2022 Jan 14;11:e73420. doi: 10.7554/eLife.73420.
7
Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study.弗雷明汉心脏研究参与者的教育流动性、衰老速度与寿命。
JAMA Netw Open. 2024 Mar 4;7(3):e240655. doi: 10.1001/jamanetworkopen.2024.0655.
8
Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging.斯威士兰感染艾滋病毒的老年人的表观遗传衰老：一项关于艾滋病毒、生活方式因素与表观遗传衰老的试点研究
Res Sq. 2023 Oct 5:rs.3.rs-3389208. doi: 10.21203/rs.3.rs-3389208/v1.
9
Associations of Epigenetic Age Estimators With Cognitive Function Trajectories in the Women's Health Initiative Memory Study.表观遗传年龄估算值与妇女健康倡议记忆研究中认知功能轨迹的关联。
Neurology. 2024 Jul 9;103(1):e209534. doi: 10.1212/WNL.0000000000209534. Epub 2024 Jun 10.
10
Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study.弗雷明汉心脏研究中的饮食、生物衰老速度与痴呆风险
Ann Neurol. 2024 Jun;95(6):1069-1079. doi: 10.1002/ana.26900. Epub 2024 Feb 26.

引用本文的文献

1
Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease.阿尔茨海默病的表观遗传时钟与纵向血浆生物标志物
medRxiv. 2025 Aug 14:2025.08.12.25333453. doi: 10.1101/2025.08.12.25333453.
2
Cortisol, DHEAS, and the cortisol/DHEAS ratio as predictors of epigenetic age acceleration.皮质醇、硫酸脱氢表雄酮以及皮质醇/硫酸脱氢表雄酮比值作为表观遗传年龄加速的预测指标。
Biogerontology. 2025 Aug 16;26(5):164. doi: 10.1007/s10522-025-10307-x.
3
Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia.基于蛋白质组学的中年或老年衰老时钟及其与痴呆症的关联风险。
Commun Med (Lond). 2025 Aug 14;5(1):353. doi: 10.1038/s43856-025-01096-y.
4
Epigenetic Clocks and Their Prospective Application in the Complex Landscape of Aging and Alzheimer's Disease.表观遗传时钟及其在衰老和阿尔茨海默病复杂领域中的潜在应用。
Genes (Basel). 2025 May 30;16(6):679. doi: 10.3390/genes16060679.
5
The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress.精力应激标志物生长分化因子15由急性心理社会应激诱导产生。
bioRxiv. 2024 Nov 29:2024.04.19.590241. doi: 10.1101/2024.04.19.590241.