Murray A B, Morrison B J
J Allergy Clin Immunol. 1986 Apr;77(4):575-81. doi: 10.1016/0091-6749(86)90348-9.
The effect of parental smoking was assessed in 94 consecutively observed children, aged 7 to 17 years, who had a history of asthmatic wheezing. The 24 children whose mothers smoked, when they were compared with children whose mothers did not smoke, had 47% more symptoms, a 13% lower mean FEV1 percent, a 23% lower mean FEF25-75%, and fourfold greater responsiveness to aerosolized histamine. A dose response was evident. There was a highly significant correlation between the results of the tests and the number of cigarettes the mother smoked while she was in the house. The differences between the children of smoking and nonsmoking mothers were greater in older than in younger subjects. The smoking habits of the father were not correlated with the severity of the child's asthma.
对94名年龄在7至17岁、有哮喘性喘息病史的儿童进行了连续观察，以评估父母吸烟的影响。与母亲不吸烟的孩子相比，母亲吸烟的24名孩子症状多47%，平均第一秒用力呼气容积（FEV1）百分比低13%，平均用力呼气中期流速（FEF25-75%）低23%，对雾化组胺的反应性高4倍。剂量反应明显。测试结果与母亲在家时吸烟的数量之间存在高度显著的相关性。吸烟母亲和不吸烟母亲的孩子之间的差异在年龄较大的孩子中比在年龄较小的孩子中更大。父亲的吸烟习惯与孩子哮喘的严重程度无关。
