Murray A B, Morrison B J
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Chest. 1992 Jan;101(1):16-8. doi: 10.1378/chest.101.1.16.
We studied 240 children with asthma who were themselves nonsmokers and had been referred consecutively to our clinic. They were aged 6 to 17 years. The severity of asthma was assessed by symptom score, by spirometry, and, in those who could perform the test reliably, by histamine bronchial challenge test. Those who reported having had a chronic or chronically relapsing itchy rash in characteristic locations were recorded as having had atopic dermatitis. Multiple analysis of variance revealed that children whose mothers smoked had significantly more severe asthma (p less than 0.001) but that atopic dermatitis had no apparent effect on the severity of asthma, either in its main effect (p = 0.71) or in its interaction with maternal smoking (p = 0.66). Although our previous study indicates that smoking mothers' children are more likely to develop asthma if they have had atopic dermatitis than if they have not, the severity of asthma does not appear to be associated with a history of atopic dermatitis. In smoking mothers' children the asthma was just as severe in those who had not had atopic dermatitis as in those who had.
我们研究了240名患有哮喘的儿童，这些儿童本人不吸烟，且是连续被转诊到我们诊所的。他们的年龄在6至17岁之间。通过症状评分、肺功能测定，以及在那些能够可靠地进行该测试的儿童中通过组胺支气管激发试验来评估哮喘的严重程度。那些报告在特征性部位有慢性或慢性复发性瘙痒皮疹的儿童被记录为患有特应性皮炎。多因素方差分析显示，母亲吸烟的儿童哮喘病情明显更严重（p<0.001），但特应性皮炎对哮喘严重程度没有明显影响，无论是其主效应（p = 0.71）还是与母亲吸烟的交互作用（p = 0.66）。尽管我们之前的研究表明，有特应性皮炎的吸烟母亲的孩子比没有特应性皮炎的孩子更易患哮喘，但哮喘的严重程度似乎与特应性皮炎病史无关。在吸烟母亲的孩子中，没有特应性皮炎的孩子和有特应性皮炎的孩子哮喘严重程度相同。
