Cartier A, Chan H, Malo J L, Pineau L, Tse K S, Chan-Yeung M
J Allergy Clin Immunol. 1986 Apr;77(4):639-45. doi: 10.1016/0091-6749(86)90359-3.
A worker developed symptoms of work-related asthma a few weeks after starting to work in a sawmill where eastern white cedar (Thuja occidentalis) was transformed into shingles. The diagnosis of occupational asthma was confirmed by monitoring of peak expiratory flow rates and bronchial responsiveness to histamine off work and at work, and specific inhalation challenges in the laboratory that demonstrated an isolated late asthmatic reaction after exposure for 4 hours to the wood dust. Specific inhalation challenges with western red cedar (thuja plicata) for 2 hours and plicatic acid (PA) for 7 minutes also caused an isolated late asthmatic reaction. Elevated specific IgE levels to PA were present. Antiserum was produced in rabbits that were immunized with PA conjugated to human serum albumin. With this antiserum in inhibition experiments, cross-reactivity between western red cedar and eastern white cedar, both belonging to the family of arborvitae, was found. It is estimated that eastern white cedar contains approximately half the amount of PA present in western red cedar.
一名工人在一家将东部白松（北美香柏）加工成木瓦的锯木厂开始工作几周后，出现了与工作相关的哮喘症状。通过监测非工作和工作时的呼气峰值流速以及支气管对组胺的反应性，以及在实验室进行的特异性吸入激发试验（该试验显示在接触木尘4小时后出现孤立的迟发性哮喘反应），确诊为职业性哮喘。对西部红松（美国扁柏）进行2小时的特异性吸入激发试验以及对扁柏酸（PA）进行7分钟的试验，也引发了孤立的迟发性哮喘反应。PA的特异性IgE水平升高。用与人类血清白蛋白偶联的PA对兔子进行免疫，制备出了抗血清。在抑制实验中使用这种抗血清，发现同为崖柏属的西部红松和东部白松之间存在交叉反应。据估计，东部白松中PA的含量约为西部红松的一半。
