Bailey D W
J Hered. 1986 Jan-Feb;77(1):17-25. doi: 10.1093/oxfordjournals.jhered.a110159.
The CXB set of recombinant inbred mouse strains provided an opportunity to observe the effects of reassorted subsets of genes on the shape of the mandible. The distances between 12 landmarks in all paired combinations were calculated to evaluate genetic control in small regions. The genetic relationships between interlandmark distances revealed genes to have most of their effects in localized regions, and the greater heritabilities usually to apply to those distances between adjacent landmarks. Interrelationships between measurements are usually explicable on a developmental basis. It is proposed that genes of this sort bring about the changes seen in organ shape during evolution. A model plan for the organization of gene activation during morphogenesis is described.
CXB重组近交系小鼠为观察基因重配子集对下颌骨形状的影响提供了契机。计算所有成对组合中12个标志点之间的距离，以评估小区域内的遗传控制。标志点间距离的遗传关系表明，基因大多在局部区域发挥作用，且较高的遗传力通常适用于相邻标志点之间的距离。测量值之间的相互关系通常可从发育角度得到解释。有人提出，这类基因导致了进化过程中器官形状的变化。本文描述了形态发生过程中基因激活组织的模型方案。
