Ward R, Collins R L, Tanguay G, Miceli D
Département de Psychologie, Université du Québec à Trois-Rivières, Canada.
J Anat. 1990 Dec;173:87-95.
The arteries of the base of the mouse brain were examined after perfusion with India ink. A qualitative difference exists between inbred mice of three strains (C57BL/6J, 129/J and BALB/cCF) on the one hand, and genetically defined heterogeneous mice on the other; the latter consistently show anomalies similar to those previously described in genetically undefined rodents, whereas inbred mice do not. A quantitative morphometric analysis of the Circle of Willis of inbred mice was undertaken. The results of this analysis are consistent with the notion that the differences in shape between the circles of Willis of different strains of inbred mice are due to additive genetic variation between these strains.
在用印度墨水灌注后，对小鼠脑底部的动脉进行了检查。一方面，三种近交系小鼠（C57BL/6J、129/J和BALB/cCF）与遗传定义的异种小鼠之间存在质的差异；后者始终表现出与先前在遗传未定义的啮齿动物中描述的类似异常，而近交系小鼠则没有。对近交系小鼠的Willis环进行了定量形态分析。该分析结果与以下观点一致，即不同近交系小鼠Willis环之间的形状差异是由于这些品系之间的加性遗传变异所致。
