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近交系小鼠脑血管变异的定量研究。

A quantitative study of cerebrovascular variation in inbred mice.

作者信息

Ward R, Collins R L, Tanguay G, Miceli D

机构信息

Département de Psychologie, Université du Québec à Trois-Rivières, Canada.

出版信息

J Anat. 1990 Dec;173:87-95.

Abstract

The arteries of the base of the mouse brain were examined after perfusion with India ink. A qualitative difference exists between inbred mice of three strains (C57BL/6J, 129/J and BALB/cCF) on the one hand, and genetically defined heterogeneous mice on the other; the latter consistently show anomalies similar to those previously described in genetically undefined rodents, whereas inbred mice do not. A quantitative morphometric analysis of the Circle of Willis of inbred mice was undertaken. The results of this analysis are consistent with the notion that the differences in shape between the circles of Willis of different strains of inbred mice are due to additive genetic variation between these strains.

摘要

在用印度墨水灌注后,对小鼠脑底部的动脉进行了检查。一方面,三种近交系小鼠(C57BL/6J、129/J和BALB/cCF)与遗传定义的异种小鼠之间存在质的差异;后者始终表现出与先前在遗传未定义的啮齿动物中描述的类似异常,而近交系小鼠则没有。对近交系小鼠的Willis环进行了定量形态分析。该分析结果与以下观点一致,即不同近交系小鼠Willis环之间的形状差异是由于这些品系之间的加性遗传变异所致。

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本文引用的文献

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Anatomical studies of the circle of Willis in normal brain.正常脑底Willis环的解剖学研究。
AMA Arch Neurol Psychiatry. 1959 Apr;81(4):409-18. doi: 10.1001/archneurpsyc.1959.02340160007002.
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Anat Rec. 1966 Sep;156(1):99-106. doi: 10.1002/ar.1091560112.
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Genetic relationships between inbred strains of mice.小鼠近交系之间的遗传关系。
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