Yuenyongchaiwat Kornanong, Akekawatchai Chareeporn, Changsri Khaimuk
Physiotherapy Department, Faculty of Allied Health Sciences, Thammasat University, Pathumthani 12120, Thailand.
Thammasat University Research Unit for Physical Therapy in Respiratory and Cardiovascular Systems, Thammasat University, Pathumthani 12120, Thailand.
Geriatrics (Basel). 2024 Nov 7;9(6):146. doi: 10.3390/geriatrics9060146.
: Older people are more likely to have poor nutrition and low muscle mass, which leads to poor physical performance and anemia, resulting in a poor quality of life and risks to mobility and mortality. Furthermore, malnutrition may, in part, raise the level of inflammatory biomarkers as well as muscle catabolism. Moreover, a range of indices related to systemic inflammation, obtained from routine complete blood count (CBC) tests, have been applied to inflammation markers. However, these biomarkers remain insufficiently addressed in the evidence supporting the presence of sarcopenia and malnutrition. This study aimed to explore sarcopenia in terms of malnutrition, anemia, and inflammation among Thai community-dwelling older people. : This study enrolled community-dwelling older people aged 60 years and above. All participants were requested to complete a questionnaire assessing for sarcopenia (SARC-F) and nutritional status using the mini nutritional assessment (MNA). In addition, blood samples were obtained for the CBC test. Logistic regression analysis explored the risk of sarcopenia, CBC, and malnutrition status. : Of 126 older people (aged 62-88 years) enrolled, 12 individuals (9.52%) had sarcopenia. Furthermore, 34.9% and 5.56% of the participants were demonstrated to have anemia and malnutrition, respectively. Nutrition status was positively associated with hemoglobin levels ( = 0.241, = 0.007) and negatively related to SARC-F scores ( = -0.190, = 0.034). Older people with anemia show an increased risk of malnutrition at an odds ratio (OR) of 3.375. Moreover, individuals with anemia were at a higher risk of developing sarcopenia (OR 4.982) than those with no anemia. However, individuals with a high level of inflammatory markers, e.g., a high systemic inflammatory response index (SIRI) and monocyte-to-lymphocyte ratio (MLR), had a higher risk of sarcopenia than those with low SIRI and MLR values. The systemic immune-inflammation index (SII) and platelet-to-lymphocyte ratio (PLR) were also positively associated with SARC-F scores. : The association between sarcopenia, malnutrition status, and anemia might overlap in clinical manifestation. In addition, future research directions regarding the utility of routine CBC testing should focus on sarcopenia and malnutrition status.
老年人更有可能存在营养不良和肌肉量低的情况，这会导致身体机能不佳和贫血，进而导致生活质量低下以及行动能力和死亡率方面的风险。此外，营养不良可能在一定程度上会提高炎症生物标志物的水平以及肌肉分解代谢。而且，从常规全血细胞计数（CBC）测试中获得的一系列与全身炎症相关的指标已被应用于炎症标志物。然而，在支持肌肉减少症和营养不良存在的证据中，这些生物标志物仍未得到充分探讨。本研究旨在探讨泰国社区居住老年人中肌肉减少症与营养不良、贫血和炎症之间的关系。
本研究招募了60岁及以上的社区居住老年人。所有参与者都被要求完成一份使用简易营养评估法（MNA）评估肌肉减少症（SARC - F）和营养状况的问卷。此外，采集血样进行CBC测试。逻辑回归分析探讨了肌肉减少症、CBC和营养不良状况的风险。
在招募的126名老年人（年龄在62 - 88岁之间）中，有12人（9.52%）患有肌肉减少症。此外，分别有34.9%和5.56%的参与者被证明患有贫血和营养不良。营养状况与血红蛋白水平呈正相关（r = 0.241，p = 0.007），与SARC - F评分呈负相关（r = -0.190，p = 0.034）。贫血的老年人出现营养不良的风险增加，优势比（OR）为3.375。此外，与无贫血的人相比，贫血患者发生肌肉减少症的风险更高（OR 4.982）。然而，炎症标志物水平高的个体，例如全身炎症反应指数（SIRI）和单核细胞与淋巴细胞比值（MLR）高的个体，比SIRI和MLR值低的个体患肌肉减少症的风险更高。全身免疫炎症指数（SII）和血小板与淋巴细胞比值（PLR）也与SARC - F评分呈正相关。
肌肉减少症、营养不良状况和贫血之间的关联在临床表现上可能存在重叠。此外，关于常规CBC检测效用的未来研究方向应聚焦于肌肉减少症和营养不良状况。
