文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

重复经颅磁刺激治疗特发性震颤的潜力有限:一项系统评价

Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review.

作者信息

Bishay Andrew A E D, Guo Anton, Desai Rhea, Mushinski Samuel, Au Andy, Swenson Andrew J, Iacoboni Marco, Bystritsky Alexander, Spivak Norman M

机构信息

Physiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

出版信息

NeuroSci. 2024 Nov 5;5(4):523-533. doi: 10.3390/neurosci5040038.


DOI:10.3390/neurosci5040038
PMID:39585106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11587431/
Abstract

Essential tremor (ET) is a prevalent movement disorder characterized by action tremors, predominantly affecting the upper limbs. While various pharmacological and non-pharmacological interventions have shown efficacy in managing ET, the therapeutic role of repetitive transcranial magnetic stimulation (rTMS) remains uncertain. This systematic review synthesizes evidence from clinical trials investigating rTMS as a treatment for ET. Despite some open-label trials reporting reductions in tremor severity, double-blinded studies revealed no significant difference between active and sham rTMS, suggesting a strong placebo effect. The findings indicate that while rTMS can reduce tremor scores, its therapeutic efficacy in ET remains unproven. Future research should focus on improving sham designs and conducting larger, rigorously controlled trials to clarify rTMS's role in ET management. Current evidence supports considering alternative treatments, such as deep brain stimulation, over rTMS for ET.

摘要

特发性震颤(ET)是一种常见的运动障碍,其特征为动作性震颤,主要影响上肢。虽然各种药物和非药物干预措施在管理ET方面已显示出疗效,但重复经颅磁刺激(rTMS)的治疗作用仍不确定。本系统评价综合了来自临床试验的证据,这些试验研究了rTMS作为ET治疗方法的效果。尽管一些开放标签试验报告震颤严重程度有所降低,但双盲研究显示,主动rTMS与假rTMS之间无显著差异,提示存在较强的安慰剂效应。研究结果表明,虽然rTMS可降低震颤评分,但其在ET中的治疗效果仍未得到证实。未来的研究应侧重于改进假刺激设计,并开展更大规模、严格对照的试验,以阐明rTMS在ET管理中的作用。目前的证据支持在ET治疗中,考虑采用深部脑刺激等替代治疗方法,而非rTMS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f7/11587431/c2d568b20829/neurosci-05-00038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f7/11587431/55ecc204edcc/neurosci-05-00038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f7/11587431/c2d568b20829/neurosci-05-00038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f7/11587431/55ecc204edcc/neurosci-05-00038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f7/11587431/c2d568b20829/neurosci-05-00038-g002.jpg

相似文献

[1]
Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review.

NeuroSci. 2024-11-5

[2]
Repetitive transcranial magnetic stimulation for post-traumatic stress disorder in adults.

Cochrane Database Syst Rev. 2024-8-2

[3]
Non-invasive brain stimulation techniques for chronic pain.

Cochrane Database Syst Rev. 2018-3-16

[4]
Non-invasive brain stimulation techniques for chronic pain.

Cochrane Database Syst Rev. 2018-4-13

[5]
Repetitive transcranial magnetic stimulation for tinnitus.

Cochrane Database Syst Rev. 2011-10-5

[6]
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.

Cochrane Database Syst Rev. 2017-1-10

[7]
Non-pharmacological interventions for improving language and communication in people with primary progressive aphasia.

Cochrane Database Syst Rev. 2024-5-29

[8]
Transcranial magnetic stimulation for the treatment of epilepsy.

Cochrane Database Syst Rev. 2016-8-11

[9]
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.

Cochrane Database Syst Rev. 2017-12-22

[10]
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.

Cochrane Database Syst Rev. 2021-4-19

本文引用的文献

[1]
Cerebellar repetitive transcranial magnetic stimulation versus propranolol for essential tremor.

Brain Behav. 2023-3

[2]
Clinical effects of continuous theta burst stimulation for generalized anxiety disorder and a mechanism involving α oscillations: a randomized controlled trial.

J Psychiatry Neurosci. 2022

[3]
Modulatory effect of continuous theta burst stimulation in patients with essential tremor.

Parkinsonism Relat Disord. 2022-1

[4]
Managing Essential Tremor.

Neurotherapeutics. 2020-10

[5]
Sleep disorders in essential tremor: systematic review and meta-analysis.

Sleep. 2020-9-14

[6]
Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018).

Clin Neurophysiol. 2020-1-1

[7]
Cerebellar repetitive transcranial magnetic stimulation (rTMS) for essential tremor: A double-blind, sham-controlled, crossover, add-on clinical trial.

Brain Stimul. 2019-10-7

[8]
Treatment of essential tremor: current status.

Postgrad Med J. 2019-10-1

[9]
MDS evidence-based review of treatments for essential tremor.

Mov Disord. 2019-5-2

[10]
The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review.

Mov Disord. 2019-4-29

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索