Chen Xue, Ma Xiaoli, Yuan Lili, Wang Fang, Zhang Yang, Cao Panxiang, Lu Yue, Chen Jiaqi, Zhou Xiaosu, Liu Hongxing
Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Department of Bone Marrow Transplantation, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Ann Hematol. 2024 Dec;103(12):6041-6043. doi: 10.1007/s00277-024-06115-x. Epub 2024 Nov 25.
This manuscript reports a rare case of CUX1::NUTM1-positive B-cell lymphoblastic leukemia (B-ALL) in a 25-year-old female patient who experienced early relapse and a poor clinical outcome. Given the rarity of NUTM1 fusion-positive B-ALL in adults, this case contributes to the growing evidence that such cases may present with a more aggressive clinical course compared to the pediatric population. Our findings suggest the need for a re-evaluation of therapeutic strategies in adult patients with this subtype of B-ALL.
本手稿报告了一例罕见的CUX1::NUTM1阳性B细胞淋巴细胞白血病（B-ALL），患者为一名25岁女性，早期复发且临床结局不佳。鉴于成人中NUTM1融合阳性B-ALL罕见，该病例进一步证明，与儿科患者相比，此类病例的临床病程可能更具侵袭性。我们的研究结果表明，需要重新评估成年B-ALL患者这一亚型的治疗策略。
