Speedy Joanna, Josling Gabrielle, Hoad Veronica C
Australian Red Cross Lifeblood, Melbourne, Victoria, Australia.
School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
Vox Sang. 2025 Mar;120(3):315-319. doi: 10.1111/vox.13776. Epub 2024 Nov 25.
In July 2019, Australia removed the upper age limit for returning donors (previously 80 years) and increased the upper age for new donors from 70 to 75 years. This study assessed the safety of our new policy for our newly eligible upper age donors (NEUADs).
For the period, 14 July 2019 to 30 June 2023, the relative risk (RR) of individual adverse events in NEUADs was compared with younger cohorts.
There were 4529 NEUADs who made 8000 donations. The overall rates of vasovagal reactions (VVRs) were significantly lower in the NEUAD cohort. However, compared with younger donors; returning NEUADs had a significantly higher rate of loss of consciousness (RR 2.62; 95% confidence interval [CI]: 1.41-4.86) and new NEUADs had a significantly higher rate of offsite VVRs (RR 1.60; 95% CI: 1.08-2.37). Both new and returning NEUADs had significantly higher rates of VVR requiring outside medical care (RR 2.48; 95% CI: 1.28-4.79 and RR 4.45; 95% CI: 2.00-9.91 respectively).
Our findings support historical findings that overall VVR rates decline with age but suggest a higher risk of more serious VVRs.
2019年7月，澳大利亚取消了对回归献血者的年龄上限（此前为80岁），并将新献血者的年龄上限从70岁提高到75岁。本研究评估了我们针对新符合年龄上限的献血者（NEUADs）的新政策的安全性。
在2019年7月14日至2023年6月30日期间，将NEUADs中个体不良事件的相对风险（RR）与较年轻队列进行比较。
有4529名NEUADs进行了8000次献血。NEUADs队列中血管迷走神经反应（VVRs）的总体发生率显著较低。然而，与年轻献血者相比，回归的NEUADs意识丧失发生率显著更高（RR 2.62；95%置信区间[CI]：1.41 - 4.86），新的NEUADs异地VVRs发生率显著更高（RR 1.60；95% CI：1.08 - 2.37）。新的和回归的NEUADs需要外部医疗护理的VVRs发生率均显著更高（分别为RR 2.48；95% CI：1.28 - 4.79和RR 4.45；95% CI：2.00 - 9.91）。
我们的研究结果支持既往研究结果，即总体VVRs发生率随年龄下降，但提示更严重VVRs的风险更高。
