Yang Chengli, Jiang Xiaoying, Ren Yuzhe, Zhu Xiaobing, Yang Junhong
Chongqing Blood Center, Jiulongpo, Chongqing, China.
Working Party on Hemovigilance of the Chinese Society of Blood Transfusion, Jiulongpo, Chongqing, China.
PLoS One. 2025 Sep 10;20(9):e0331838. doi: 10.1371/journal.pone.0331838. eCollection 2025.
In 2012, China raised the upper age restriction for blood donors from 55 to 60 years old. This study analyzed the impact of raising the upper age restriction on whole blood donor health, contribution to blood supply, and safety of blood.
The blood collection and donor hemovigilance data of the Chongqing Blood Center from 2012 to 2023 were analyzed to evaluate the safety of elderly blood donors. To evaluate the impact on blood donor and blood component safety, the number of blood donors and donations, the rate and causes of deferrals, donor health (vasovagal reaction risk), and the screening results of transfusion-transmitted infectious diseases of elderly blood donors (56-60 years) were compared to young blood donors (18-55 years).
During the 12-year period, the proportion of elderly blood donors in whole blood donations increased 10-fold (0.19% to 1.89%), and the proportion of blood collections increased by the same factor (0.20% to 2.15%). Lower deferral rates were observed among older male donors compared to younger ones, whereas the reverse was found in females. A lower incidence of vasovagal reactions and positive HBV, HCV, and syphilis screening rates was found among male and female elderly blood donors compared to young blood donors. In contrast, the positive HIV reaction rate of older female donors was higher than that of young female blood donors.
This study finds an increasing frequency of donors aged 56-60. Deferral rates are lower among older male donors compared to young, but the reverse is seen in females. In addition, VVR rates and HCV, HBV and syphilis incidences are lower in old donors, but HIV rates appear highest among older donors.
2012年，中国将献血者的年龄上限从55岁提高到了60岁。本研究分析了提高年龄上限对全血献血者健康、血液供应贡献以及血液安全性的影响。
分析重庆血液中心2012年至2023年的采血和献血者血液警戒数据，以评估老年献血者的安全性。为评估对献血者和血液成分安全性的影响，将老年献血者（56 - 60岁）与年轻献血者（18 - 55岁）的献血者数量和献血量、延期率及原因、献血者健康状况（血管迷走神经反应风险）以及输血传播感染疾病的筛查结果进行了比较。
在这12年期间，全血献血中老年献血者的比例增长了10倍（从0.19%增至1.89%），采血比例也增长了相同倍数（从0.20%增至2.15%）。与年轻男性献血者相比，老年男性献血者的延期率较低，而女性情况则相反。与年轻献血者相比，老年男性和女性献血者的血管迷走神经反应发生率以及乙肝、丙肝和梅毒筛查阳性率较低。相比之下，老年女性献血者的艾滋病毒阳性反应率高于年轻女性献血者。
本研究发现56 - 60岁献血者的频率在增加。老年男性献血者的延期率低于年轻人，但女性情况相反。此外，老年献血者的血管迷走神经反应率以及丙肝、乙肝和梅毒发病率较低，但艾滋病毒感染率在老年献血者中似乎最高。
