全身炎症反应指数与胃癌临床及组织病理学特征的关系

The relationship between systemic inflammation response index and clinical and histopathological features in gastric cancer.

作者信息

Pehlevan-Özel Hikmet, Dinç Tolga, Okay Nermin D, Tez Mesut

机构信息

Department of Surgery, Mamak State Hospital, Ankara, Turkey.

Department of General Surgery, School of Medicine, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

出版信息

Cir Cir. 2024 Nov 25;93(2):158-165. doi: 10.24875/CIRU.23000234.

DOI:10.24875/CIRU.23000234

PMID:39586328

Abstract

OBJECTIVE

The systemic inflammation response index (SIRI) is a marker used to predict survival. The aim of this study is to examine the relationship between SIRI and clinicopathological features and survival.

METHOD

The relationship between clinicopathological characteristics and survey and SIRI was retrospectively investigated.

RESULTS

A total of 178 patients were included in the study. Poor prognostic factors such as tumor size, t, T-stage, tumor-node-metastasis (TNM) stage, and CA19-9 level were found to have a statistically significant relationship with patients with high SIRI (p = 0.039, p = 0.001, p = 0.001 and p = 0.013, respectively). A high SIRI was found to be an independent and poor prognostic factor for 3-year and 5-year survival (p = 0.014 and p = 0.027, respectively).

CONCLUSIONS

High SIRI was associated with a poor survival rate, as were advanced TNM stage, advanced T stage, larger tumor size, and elevated CA19-9 level; all these are poor prognostic markers for gastric cancer.

摘要

目的

全身炎症反应指数（SIRI）是一种用于预测生存率的标志物。本研究旨在探讨SIRI与临床病理特征及生存率之间的关系。

方法

回顾性研究临床病理特征与SIRI之间的关系。

结果

本研究共纳入178例患者。发现肿瘤大小、t、T分期、肿瘤-淋巴结-转移（TNM）分期和CA19-9水平等不良预后因素与高SIRI患者存在统计学显著关系（分别为p = 0.039、p = 0.001、p = 0.001和p = 0.013）。高SIRI被发现是3年和5年生存率的独立不良预后因素（分别为p = 0.014和p = 0.027）。