Chinigò Giorgia, Ruffinatti Federico Alessandro, Munaron Luca
University of Turin, Department of Life Sciences and Systems Biology, via Accademia Albertina 13, 10123 Turin, Italy.
Biochim Biophys Acta Rev Cancer. 2024 Nov;1879(6):189226. doi: 10.1016/j.bbcan.2024.189226. Epub 2024 Nov 23.
Prostate cancer (PCa) is the second deadliest cancer among men worldwide. Particularly critical is its development towards metastatic androgen-independent forms for which the current therapies are ineffective. Indeed, the 5-year relative survival for PCa drops dramatically to 34 % in the presence of metastases. The superfamily of Transient Receptor Potential (TRP) channels could answer the urgent request to identify new prognostic and therapeutic tools against metastatic PCa. Indeed, this class of ion channels revealed an appealing de-regulation during PCa development and its progression towards aggressive forms. Altered expression and/or functionality of several TRPs have been associated with the PCa metastatic cascade by significantly impacting tumor growth, invasiveness, and angiogenesis. In this review, we will dissect the contribution of TRP channels in such hallmarks of PCa and then discuss their applicability as new prognostic and therapeutic agents in the fight against metastatic PCa. In particular, the great potential of TRPM8, TRPV6, and TRPA1 in opening the way to new treatment perspectives will be highlighted.
前列腺癌（PCa）是全球男性中第二大致命性癌症。尤其关键的是，它会发展为转移性雄激素非依赖性形式，而目前的治疗方法对此无效。事实上，出现转移时，PCa的5年相对生存率会急剧降至34%。瞬时受体电位（TRP）通道超家族可能满足识别针对转移性PCa的新预后和治疗工具的迫切需求。的确，这类离子通道在PCa发展及其向侵袭性形式进展过程中显示出令人感兴趣的失调。几种TRP的表达和/或功能改变与PCa转移级联相关，对肿瘤生长、侵袭性和血管生成有显著影响。在本综述中，我们将剖析TRP通道在PCa这些特征中的作用，然后讨论它们作为对抗转移性PCa的新预后和治疗药物的适用性。特别是，将强调TRPM8、TRPV6和TRPA1在开辟新治疗前景方面的巨大潜力。
