Kong Weiming, Liang Shikai, Abel Sene Kevin, Lv Xianli
Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, China.
International Department, Chifeng University Affiliated Hospital, Chifeng University, China.
Neuroradiol J. 2025 Aug;38(4):438-449. doi: 10.1177/19714009241303056. Epub 2024 Nov 25.
To analyze the hemodynamic changes caused by arteriovenous malformation (AVM) and AVM embolization through a meta-analysis of the existing literature. Search for relevant studies on PubMed/Medline until November 7, 2023, and further screen the bibliographies of relevant studies to ensure comprehensive search. According to the PRISMA guidelines, manuscripts were selected to provide local hemodynamic information on AVM arterial feeders and drainage veins. A total of 13 studies were included in the final analysis. The diameter of the supplying artery (y = 0.002x + 2.24, R = 0.99) and flow velocity (y = 0.09x + 54.55, R = 0.92) had a positive linear relationship with cerebral blood flow. The pressure difference through the small AVM nidus was higher than that in the large AVM, with values of (y = -12.23x + 101.39, R = 0.96). There was a negative linear correlation between the sessions of AVM embolization and blood flow (1 session: y = -150.7x + 564.97, R = 0.98 and 4 sessions: y = -118.81x + 750.07, R = 0.99). There was a positive linear relationship between the increase in arterial pressure, peri-AVM parenchymal perfusion, and the percentage of occlusion in the medium-sized AVMs. However, this correlation was a nonlinear relationship between elevated arterial pressure, peri-AVM parenchymal perfusion, and the percentage of large AVM occlusion. The hemodynamic changes of AVM (in the feeding arteries, compartments of AVM, and draining veins) follow a linear relationship. The impact of embolization on hemodynamics in medium and small AVMs follows a linear relationship. The impact of embolization of large AVMs on hemodynamics follows a nonlinear relationship.
通过对现有文献的荟萃分析，分析动静脉畸形（AVM）及其栓塞引起的血流动力学变化。在PubMed/Medline上检索截至2023年11月7日的相关研究，并进一步筛选相关研究的参考文献以确保全面检索。根据PRISMA指南，选择提供AVM供血动脉和引流静脉局部血流动力学信息的手稿。最终分析纳入了13项研究。供血动脉直径（y = 0.002x + 2.24，R = 0.99）和血流速度（y = 0.09x + 54.55，R = 0.92）与脑血流量呈正线性关系。通过小AVM病灶的压力差高于大AVM，其值为（y = -12.23x + 101.39，R = 0.96）。AVM栓塞次数与血流量呈负线性相关（1次栓塞：y = -150.7x + 564.97，R = 0.98；4次栓塞：y = -118.81x + 750.07，R = 0.99）。在中型AVM中，动脉压升高、AVM周围实质灌注与闭塞百分比之间呈正线性关系。然而，在大型AVM中，动脉压升高、AVM周围实质灌注与闭塞百分比之间的这种相关性是非线性关系。AVM（在供血动脉、AVM腔室和引流静脉中）的血流动力学变化呈线性关系。栓塞对中小AVM血流动力学的影响呈线性关系。栓塞对大型AVM血流动力学的影响呈非线性关系。
