Department of Cancer Biology, Emory School of Medicine, Atlanta, GA, USA.
Wallace H. Coulter Department of Biomedical Engineering, Emory School of Medicine, Atlanta, GA, USA.
Adv Exp Med Biol. 2024;1465:37-53. doi: 10.1007/978-3-031-66686-5_3.
Obesity is a risk factor for developing breast cancer, and significantly increases mortality rates in patients diagnosed with this disease. Drivers of this unfortunate relationships are multifactorial, with obesity-induced changes in the epigenetic state of breast cancer cells being identified as a critical mechanism that impact survival, metastasis, and therapeutic responses. Recent studies have investigated the epigenetic landscape of breast cancer to elucidate the molecular interplay between the breast tissue epigenome and its cellular microenvironment. This chapter highlights studies that demonstrates the impact of obesity on the epigenome and metabolome of breast cancer cells. Furthermore, we discuss how obesity impacts the efficacy of chemotherapy and epigenetic targeting drugs, including the emergence of drug-resistance clonal populations. Delineating the relationships between the obesity and epigenetic changes in breast cancer cells will help identify therapeutic strategies which could improve survival outcomes in the rapidly growing number of patients with obesity and cancer.
肥胖是乳腺癌发病的一个风险因素，并且显著增加了患有这种疾病的患者的死亡率。造成这种不幸关系的因素是多方面的，肥胖引起的乳腺癌细胞表观遗传状态的改变被认为是影响生存、转移和治疗反应的关键机制。最近的研究已经调查了乳腺癌的表观遗传景观，以阐明乳腺组织表观基因组与其细胞微环境之间的分子相互作用。本章重点介绍了研究肥胖对乳腺癌细胞表观基因组和代谢组的影响。此外，我们还讨论了肥胖如何影响化疗和表观遗传靶向药物的疗效，包括耐药克隆群体的出现。阐明肥胖与乳腺癌细胞表观遗传变化之间的关系将有助于确定治疗策略，这些策略可以改善日益增长的肥胖和癌症患者的生存结果。
