Upadhyay Shreya, Kumar Shashi, Singh Vishal Kumar, Tiwari Rahul, Kumar Awnish, Sundar Shyam, Kumar Rajiv
Expert Rev Mol Med. 2024 Nov 26;27:1-55. doi: 10.1017/erm.2024.36.
Leishmaniasis, caused by obligate intracellular parasites, poses a significant global health burden. The control of infection relies on an effective T cell-dependent immune response; however, various factors impede the host’s ability to mount a successful defence. Alterations in the chemokine profile, responsible for cell trafficking to the infection site, can disrupt optimal immune responses and influence the outcome of pathogenesis by facilitating parasite persistence. This review aims to emphasize the significance of the chemokine system in T cell responses and to summarize the current knowledge on the dysregulation of chemokines and their receptors associated with different subsets of T lymphocytes during Leishmaniasis. A comprehensive understanding of the dynamic nature of the chemokine system during Leishmaniasis is crucial for the development of successful immunotherapeutic approaches.
利什曼病由专性细胞内寄生虫引起，给全球健康带来重大负担。感染的控制依赖于有效的T细胞依赖性免疫反应；然而，多种因素阻碍宿主成功进行防御的能力。负责细胞向感染部位迁移的趋化因子谱的改变，会破坏最佳免疫反应，并通过促进寄生虫持续存在来影响发病机制的结果。本综述旨在强调趋化因子系统在T细胞反应中的重要性，并总结目前关于利什曼病期间与不同T淋巴细胞亚群相关的趋化因子及其受体失调的知识。全面了解利什曼病期间趋化因子系统的动态性质对于开发成功的免疫治疗方法至关重要。
