既往广泛溃疡对溃疡性结肠炎患者粪便钙卫蛋白的影响。

Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis.

作者信息

Ishida Natsuki, Egami Takatoshi, Takebe Tomohiro, Takahashi Kenichi, Asai Yusuke, Tamura Satoshi, Matsuura Tomoharu, Yamade Mihoko, Iwaizumi Moriya, Hamaya Yasushi, Yamada Takanori, Osawa Satoshi, Sugimoto Ken

机构信息

First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Shizuoka, Hamamatsu, 431-3192, Japan.

Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

出版信息

BMC Gastroenterol. 2024 Nov 25;24(1):426. doi: 10.1186/s12876-024-03522-2.

DOI:10.1186/s12876-024-03522-2

PMID:39587487

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11587621/

Abstract

BACKGROUND

Ulcerative colitis (UC) causes extensive ulceration attributable to intestinal inflammation. This study investigated the effect of past extensive ulcers (PEUs) on fecal calprotectin (FC).

METHODS

This retrospective, single-center, observational study included patients with UC with a Mayo endoscopic subscore of 0. UC with scarring or pseudopolyposis was defined as PEU and FC and fecal immunochemical occult blood test (FIT) values were compared. The marker levels of patients in the PEU and non-PEU groups were examined to assess clinical relapse within 12 months.

RESULTS

Of the 61 included patients, 27 had UC with PEUs and 34 had UC without PEUs. Albumin, hemoglobin, and FIT values between groups were not significantly different; however, the C-reactive protein and FC values of the PEU group were significantly higher than those of the non-PEU group. The FC values of the clinical relapse and remission groups within 12 months differed significantly. The cutoff values for the prediction of relapse within 12 months for all patients (area under the curve [AUC], 0.709; 95% confidence interval [CI], 0.512-0.907) and the non-PEU group (AUC, 0.893; 95% CI, 0.724-1.000) were both 118 mg/kg.

CONCLUSIONS

UC patients with PEUs have higher FC values than those without PEUs, even in remission. Additionally, FC values do not predict relapse in PEU patients. Therefore, FC may not be a sufficiently accurate biomarker for patients with PEUs.

摘要

背景

溃疡性结肠炎（UC）可导致因肠道炎症引起的广泛溃疡。本研究调查了既往广泛溃疡（PEU）对粪便钙卫蛋白（FC）的影响。

方法

这项回顾性、单中心、观察性研究纳入了Mayo内镜亚评分为0的UC患者。将伴有瘢痕形成或假息肉形成的UC定义为PEU，并比较FC和粪便免疫化学潜血试验（FIT）值。检查PEU组和非PEU组患者的标志物水平，以评估12个月内的临床复发情况。

结果

在纳入的61例患者中，27例患有伴有PEU的UC，34例患有不伴有PEU的UC。两组之间的白蛋白、血红蛋白和FIT值无显著差异；然而，PEU组的C反应蛋白和FC值显著高于非PEU组。12个月内临床复发组和缓解组的FC值有显著差异。所有患者（曲线下面积[AUC]，0.709；95%置信区间[CI]，0.512 - 0.907）和非PEU组（AUC，0.893；95%CI，0.724 - 1.000）预测12个月内复发的临界值均为118mg/kg。