Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
BMC Ophthalmol. 2024 Nov 25;24(1):508. doi: 10.1186/s12886-024-03775-1.
Orbital Castleman's disease is a rare benign lymphoproliferative disorder of extranodal origin.
A 72-year-old man presented with bilateral upper eyelid swelling. Radiology revealed enlarged lacrimal glands in both eyes. Castleman's disease (plasma cell type) was confirmed by histo-immunochemical examinations after excision of the left orbital mass. No extraorbital involvement was found in systemic evaluation. Postoperatively, corticosteroid therapy was given. After 1 year of follow-up, there was no recurrence in the left orbit, and the swelling of the right eyelid was improved.
Here, we report a case of orbital Castleman's disease involving the lacrimal gland bilaterally and summarize previously reported cases. For bilateral orbital masses, the possibility of Castleman's disease should be considered. Before the diagnosis, it is necessary to fully distinguish from other diseases such as IgG4-related eye diseases.
眼眶 Castleman 病是一种罕见的淋巴结外起源的良性淋巴组织增生性疾病。
一名 72 岁男性因双侧上眼睑肿胀就诊。影像学检查显示双眼泪腺增大。切除左眼眶内肿块后，组织免疫化学检查证实为 Castleman 病（浆细胞型）。全身评估未发现眼眶外受累。术后给予皮质类固醇治疗。随访 1 年后，左眼无复发，右眼肿胀改善。
我们在此报告一例累及双侧泪腺的眼眶 Castleman 病，并总结了以往报道的病例。对于双侧眼眶肿块，应考虑 Castleman 病的可能性。在诊断之前，有必要与 IgG4 相关眼病等其他疾病充分鉴别。
