Bernetti Caterina, Di Gennaro Gianfranco, Brunelli Nicoletta, Marcosano Marilena, Altamura Claudia, Liaci Giorgio, Anzalone Desirè, Vernieri Fabrizio, Beomonte Zobel Bruno, Mallio Carlo A
Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Research Unit of Diagnostic Imaging, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Neuroradiol J. 2025 Apr;38(2):207-213. doi: 10.1177/19714009241303117. Epub 2024 Nov 26.
This research seeks to investigate correlations between enlarged Perivascular Spaces (PVSs) and clinical/imaging data, such as information obtained through Doppler analysis, in a population with young and middle-age stroke. We retrospectively reviewed demographics, clinical and MRI data, of 163 patients, with MRI confirmed stroke. All patients underwent ECD TSA (Eco-Color-Doppler of the Supra-aortic Trunks) and TCCD (Transcranial Eco-color-Doppler), to study extra or intracranial stenosis, presence and composition of plaques. Severity of PVS was evaluated on T2-weighted images according to the Potter scale. To identify potential predictors of PVSs, an exploratory backward stepwise ordinal regression model was developed, including clinical and Doppler US variables. In the stepwise ordered logistic regression analysis with PVSs at BG (Basal Ganglia) as the outcome, hemodynamically significant stenosis in any vessel ipsilateral to the ischemic lesion displayed a significant positive association with a higher outcome value. Similar results were observed for ESUS (Embolic Stroke of Undetermined Source). Fibrolipid plaques in any vase exhibited a significant negative association. At MB (Midbrain), male patients and subjects with hypertension exhibited a higher value of PVSs. Dyslipidemia demonstrated a significant negative effect. When PVSs were investigated in the CS (Centrum Semiovale), no statistically significant association with the extent of PVSs emerged. These insights not only enhance our understanding of the role of PVSs in cerebrovascular health in a young and middle-age population but also highlight the potential of PVSs as a biomarker in neuroimaging studies, warranting further research to elucidate their clinical implications and underlying pathophysiological mechanisms.
本研究旨在调查年轻和中年卒中人群中扩大的血管周围间隙（PVSs）与临床/影像学数据之间的相关性，例如通过多普勒分析获得的信息。我们回顾性分析了163例经MRI证实为卒中患者的人口统计学、临床和MRI数据。所有患者均接受了ECD TSA（主动脉弓上干彩色多普勒超声）和TCCD（经颅彩色多普勒超声）检查，以研究颅外或颅内狭窄、斑块的存在和成分。根据波特量表在T2加权图像上评估PVS的严重程度。为了确定PVSs的潜在预测因素，我们建立了一个探索性向后逐步有序回归模型，包括临床和多普勒超声变量。在以基底节（BG）的PVSs为结果的逐步有序逻辑回归分析中，缺血性病变同侧任何血管的血流动力学显著狭窄与较高的结果值呈显著正相关。不明来源栓塞性卒中（ESUS）也观察到类似结果。任何血管中的纤维脂质斑块呈显著负相关。在中脑（MB），男性患者和高血压患者的PVSs值较高。血脂异常显示出显著的负面影响。当在半卵圆中心（CS）研究PVSs时，未发现与PVSs范围有统计学意义的关联。这些见解不仅加深了我们对年轻和中年人群中PVSs在脑血管健康中作用的理解，也突出了PVSs作为神经影像学研究中生物标志物的潜力，值得进一步研究以阐明其临床意义和潜在的病理生理机制。
