Poostiyan Nazila, Barati Mahbube, Shahmoradi Zabiholah, Saber Mina
Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Cosmet Dermatol. 2025 Feb;24(2):e16676. doi: 10.1111/jocd.16676. Epub 2024 Nov 26.
Actinic keratosis (AK) is a common skin condition treated by dermatologists; however, the effectiveness, superiority, and potential side effects of current treatment protocols are still debated.
This study aimed to compare the effectiveness and safety of 5% fluorouracil topical cream and 1% niacinamide topical gel in patients with AK.
In a randomized clinical trial, 26 patients with 95 AK lesions were assigned to receive either 5% fluorouracil topical cream twice daily for 4 weeks or 1% niacinamide topical gel twice daily for 3 months. Photography and dermoscopy before and after treatment were used to evaluate the outcomes.
The study included 26 patients who underwent randomization and treatment. Analysis of the improvement response after treatment through photography and dermoscopy scores, as well as patients' perspectives, showed that the fluorouracil group had significantly better outcomes than the niacinamide group. However, treatment complications including burning, itching, and erythema were significantly more frequent in the fluorouracil group than in the niacinamide group.
Although 5% fluorouracil cream is more effective than 1% niacinamide gel in treating AK lesions, it is also associated with more frequent side effects.
光化性角化病（AK）是皮肤科医生治疗的常见皮肤病；然而，目前治疗方案的有效性、优越性和潜在副作用仍存在争议。
本研究旨在比较5%氟尿嘧啶外用乳膏和1%烟酰胺外用凝胶治疗AK患者的有效性和安全性。
在一项随机临床试验中，26例患有95处AK皮损的患者被分配接受每日两次5%氟尿嘧啶外用乳膏治疗4周或每日两次1%烟酰胺外用凝胶治疗3个月。治疗前后采用摄影和皮肤镜检查来评估疗效。
该研究纳入了26例接受随机分组和治疗的患者。通过摄影和皮肤镜检查评分以及患者的反馈对治疗后的改善反应进行分析，结果显示氟尿嘧啶组的疗效明显优于烟酰胺组。然而，氟尿嘧啶组的治疗并发症（包括烧灼感、瘙痒和红斑）明显比烟酰胺组更频繁。
虽然5%氟尿嘧啶乳膏在治疗AK皮损方面比1%烟酰胺凝胶更有效，但它也伴有更频繁的副作用。
