Shulman D I, Martinez C R, Bercu B B, Root A W
J Pediatr. 1986 Apr;108(4):540-4. doi: 10.1016/s0022-3476(86)80830-7.
In a series of 37 consecutive CT scans performed in children referred to our pediatric endocrine unit, an empty (eight) or partially empty (one) sella turcica was found in nine (24%) patients with short stature or delay in sexual maturation, precocious puberty, or hypoparathyroidism. The size and contour of the sella were abnormal in only three patients. Five of the nine children had evidence of decreased growth hormone secretion as determined by subnormal GH secretory responses to provocative tests (peak GH concentration less than 7 ng/ml) or assessment of endogenous 24-hour GH secretion (mean 24-hour GH concentration less than 3 ng/ml). Two children had multiple pituitary hormone deficiencies. Although primary empty sella syndrome was often associated with hypothalamic-pituitary dysfunction in this series, the prevalence of an empty sella in normal children is unknown. Further identification and evaluation of children with empty sella may provide new information regarding the cause of pituitary dysfunction in childhood.
在转诊至我们儿科内分泌科的儿童中进行的连续37次CT扫描系列中，在9名（24%）身材矮小或性成熟延迟、性早熟或甲状旁腺功能减退的患者中发现了空蝶鞍（8例）或部分空蝶鞍（1例）。仅3例患者蝶鞍的大小和轮廓异常。通过对激发试验的生长激素分泌反应低于正常（生长激素峰值浓度低于7 ng/ml）或评估内源性24小时生长激素分泌（平均24小时生长激素浓度低于3 ng/ml），确定9名儿童中有5名有生长激素分泌减少的证据。2名儿童有多垂体激素缺乏症。虽然在该系列中，原发性空蝶鞍综合征常与下丘脑-垂体功能障碍相关，但正常儿童中空蝶鞍的患病率尚不清楚。对空蝶鞍儿童的进一步识别和评估可能会提供有关儿童垂体功能障碍病因的新信息。
