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大鼠正畸牙齿移动过程中功能低下牙齿中成骨细胞和破骨细胞的数量。

The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats.

机构信息

Orthodontic Postgraduate Education Program, Faculty of Dentistry, Gadjah Mada University, Sleman, Yogyakarta, 55281, Indonesia.

Department of Orthodontics, Faculty of Dentistry, Gadjah Mada University, Sleman, Yogyakarta, 55281, Indonesia.

出版信息

F1000Res. 2022 Jun 13;10:541. doi: 10.12688/f1000research.53728.1. eCollection 2021.

DOI:10.12688/f1000research.53728.1
PMID:39588468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11587237/
Abstract

When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D ), five (D ), and 10 (D ) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p> 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D was the same at D (p = 0.99), but significantly higher (p = 0.002), than D The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p <0.05). The number of osteoclasts in the NO D group was significantly higher than the other groups (p <0.05). The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement.

摘要

当牙齿受到正畸力移动时，功能不足的牙齿相对于正常牙齿的牙齿移动速度会降低。本研究旨在确定在正畸牙齿移动过程中，功能不足牙齿的张力侧成骨细胞数量和压力侧破骨细胞数量。18 只雄性 Wistar 大鼠在上颌切牙上施加腭部螺旋弹簧。将大鼠分为两组，正常咬合（NO）组和功能不足咬合（HO）组。在第 0 天（D）、第 5 天（D）和第 10 天（D）测试张力侧成骨细胞数量和压力侧破骨细胞数量，采用双因素方差分析。通过苏木精-伊红染色进行观察。结果表明，HO 组张力侧成骨细胞数量与 NO 组相同（p>0.05）。NO 和 HO 组在 D 时张力侧成骨细胞数量与 D 时相同（p=0.99），但显著高于 D（p=0.002）。HO 组压力侧破骨细胞数量明显低于 NO 组（p<0.05）。NO 组 D 时破骨细胞数量明显高于其他组（p<0.05）。功能不足状态不会影响张力侧成骨细胞数量，但会减少正畸牙齿移动过程中压力侧破骨细胞数量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/c9f8b32f01f7/f1000research-10-134578-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/e9508fa0b840/f1000research-10-134578-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/54a27aa61e8a/f1000research-10-134578-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/2ee3ca122c70/f1000research-10-134578-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/c9f8b32f01f7/f1000research-10-134578-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/e9508fa0b840/f1000research-10-134578-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/54a27aa61e8a/f1000research-10-134578-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/2ee3ca122c70/f1000research-10-134578-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d88/11698512/c9f8b32f01f7/f1000research-10-134578-g0003.jpg

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本文引用的文献

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F1000Res. 2019 Dec 10;8:2074. doi: 10.12688/f1000research.21211.2. eCollection 2019.
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