d'Apuzzo Fabrizia, Cappabianca Salvatore, Ciavarella Domenico, Monsurrò Angela, Silvestrini-Biavati Armando, Perillo Letizia
Department of Orthodontics, Second University of Naples, Naples, Italy.
ScientificWorldJournal. 2013 Apr 23;2013:105873. doi: 10.1155/2013/105873. Print 2013.
Biologically active substances are expressed by cells within the periodontium in response to mechanical stimuli from orthodontic appliances. Several possible biomarkers representing biological modifications during specific phenomena as simile-inflammatory process, bone resorption and formation, periodontal ligament changes, and vascular and neural responses are proposed. Citations to potentially published trials were conducted by searching PubMed, Cochrane databases, and scientific textbooks. Additionally, hand searching and contact with experts in the area were undertaken to identify potentially relevant published and unpublished studies. Selection criteria were as follows: animal models involving only mice and rats undergoing orthodontic treatment; collection of gingival crevicular fluid (GCF) as a noninvasively procedure for humans; no other simultaneous treatment that could affect experimental orthodontic movement. The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. The relevance for clinicians of evaluating the rate of some substances as valid biomarkers of periodontal effects during orthodontic movement, by means of two models of study, mice and men, is underlined.
生物活性物质由牙周组织内的细胞表达，以响应正畸矫治器产生的机械刺激。人们提出了几种可能的生物标志物，它们代表了特定现象（如类炎症过程、骨吸收与形成、牙周韧带变化以及血管和神经反应）期间的生物学改变。通过检索PubMed、Cochrane数据库和科学教科书，获取了可能已发表试验的参考文献。此外，还进行了手工检索并与该领域的专家联系，以识别潜在相关的已发表和未发表研究。选择标准如下：仅涉及接受正畸治疗的小鼠和大鼠的动物模型；作为对人类的非侵入性程序收集龈沟液（GCF）；不存在可能影响正畸实验性移动的其他同时进行的治疗。数据表明，了解正畸和矫形治疗期间牙周组织中发生的重塑过程可能是一种具有临床实用性的程序，有助于正确选择机械应力以改善和缩短治疗周期，避免不良后果。强调了临床医生通过小鼠和人类这两种研究模型评估某些物质作为正畸移动期间牙周效应有效生物标志物的速率的相关性。
