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成人活体肝移植中右后叶供肝的应用:单中心 17 年经验报告。

Right Posterior Segment Graft in Adult Living-Donor Liver Transplantation: A Report of 17 Years of Experience at a Single Institution.

机构信息

From the Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan and the Department of Hepatobiliary Pancreatic and Transplantation/Pediatric Surgery, Kyoto University, Kyoto, Japan.

出版信息

Exp Clin Transplant. 2024 Oct;22(10):786-793. doi: 10.6002/ect.2024.0239.

Abstract

OBJECTIVES

The right posterior segment graft can be selected in cases where neither the right nor left lobe graft satisfies the selection criteria for adult living donor liver transplant. However, vascular and biliary anatomy may cause technical difficulties in procurement of posterior segments in donors of living donor liver transplant and may require specific attention in vascular and biliary reconstruction in the recipient. In this study, we examined the feasibility of right posterior segment grafts in adult living donor liver transplants through donor safety and recipient outcomes and clarified the anatomic points of the surgical technique.

MATERIALS AND METHODS

We retrospectively reviewed 296 cases of adult living donor liver transplants treated at Kumamoto University between August 2000 and March 2017.

RESULTS

Among 296 cases, graft types were right lobe (n = 162), left lobe (n = 119), and right posterior segments (n = 9). Among donors, no significant differences were shown in operative time, blood loss, or incidence of postoperative complications between early and late phases among the 3 groups. Four cases ofright posterior segment had >2 biliary duct stumps, and 2 cases had 2 portal vein stumps. Among recipients, median actual graft-to-recipient weight ratio was 0.82% (range, 0.52%-1.22%), with no factors, including graft type, significantly associated with graft survival. Hepatic artery thrombosis and rupture of hepatic artery pseudoaneurysm occurred in 1 case as an early complication, and biliary anastomotic stricture occurred in 4 cases as a late complication.

CONCLUSIONS

The right posterior segment graft may be an effective alternative in living donor liver transplant when no eligible candidates for conventional grafts are available among families and relatives. Careful preoperative anatomic evaluations and simulations are important.

摘要

目的

当右叶或左叶供肝均不符合成人活体肝移植的选择标准时,可以选择右后叶供肝。然而,在活体肝移植供者中,后叶的血管和胆道解剖结构可能会导致获取供肝时存在技术困难,并且在受体中进行血管和胆道重建时需要特别注意。本研究通过供者安全性和受者结局来检验成人活体肝移植中右后叶供肝的可行性,并阐明手术技术的解剖要点。

材料和方法

我们回顾性分析了 2000 年 8 月至 2017 年 3 月期间在熊本大学接受成人活体肝移植治疗的 296 例患者的临床资料。

结果

在 296 例患者中,供肝类型为右叶(n = 162)、左叶(n = 119)和右后叶(n = 9)。在供者中,3 组之间手术时间、术中出血量或术后并发症发生率在早期和晚期之间无显著差异。4 例右后叶有超过 2 个胆管残端,2 例有 2 个门静脉残端。在受者中,实际供肝与受体体重比的中位数为 0.82%(范围:0.52%-1.22%),包括供肝类型在内的任何因素与供肝存活率均无显著相关性。1 例发生早期并发症为肝动脉血栓形成和假性肝动脉动脉瘤破裂,4 例发生晚期并发症为胆吻合口狭窄。

结论

当家族和亲属中没有合适的常规供肝候选者时,右后叶供肝可能是活体肝移植的有效替代选择。仔细的术前解剖评估和模拟非常重要。

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