Otorhinolaryngology-Head and Neck Surgery, Peking University Third Hospital, Peking University, Beijing, Beijing 100000, China.
Peking University Health Science Center, Peking University, Beijing, Beijing 100000, China.
Eur J Dermatol. 2024 Oct 1;34(5):463-471. doi: 10.1684/ejd.2024.4748.
Palmoplantar pustulosis (PPP) is a chronic relapsing inflammatory disease of unknown aetiology characterized by erythema, scaling, and aseptic pustules, which pose a significant clinical, psychological, and economic burden to patients. Studies have shown that the tonsils play a key role in the exacerbation and pathogenesis of certain diseases. This paper systematically summarizes the evidence supporting the close association between tonsils and PPP, and proposes mechanisms by which tonsils may contribute to the pathogenesis of PPP. In addition, the paper elucidates the role of tonsillectomy in alleviating PPP, provides a basis for considering it as a treatment option after conventional PPP treatment has failed, and lays the groundwork for an in-depth investigation of the intricate relationship between tonsillectomy and PPP.
掌跖脓疱病（PPP）是一种病因不明的慢性复发性炎症性疾病，其特征为红斑、鳞屑和无菌脓疱，给患者带来了巨大的临床、心理和经济负担。研究表明，扁桃体在某些疾病的恶化和发病机制中起着关键作用。本文系统总结了支持扁桃体与 PPP 密切相关的证据，并提出了扁桃体可能导致 PPP 发病机制的机制。此外，本文阐明了扁桃体切除术在缓解 PPP 中的作用，为在常规 PPP 治疗失败后考虑将其作为一种治疗选择提供了依据，并为深入研究扁桃体切除术与 PPP 之间的复杂关系奠定了基础。
