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扁桃体切除术或腺样体扁桃体切除术与慢性/复发性急性扁桃体炎的非手术治疗对比

Tonsillectomy or adeno-tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis.

作者信息

Burton Martin J, Glasziou Paul P

机构信息

Department of Otolaryngology - Head and Neck Surgery, Oxford Radcliffe Hospitals NHS Trust, Level LG1, West Wing, John Radcliffe Hospital, Oxford, UK, OX3 9DU.

出版信息

Cochrane Database Syst Rev. 2009 Jan 21(1):CD001802. doi: 10.1002/14651858.CD001802.pub2.

Abstract

BACKGROUND

Surgical removal of the tonsils, with or without adenoidectomy (adeno-/tonsillectomy), is a common ENT operation but the indications for surgery are controversial.

OBJECTIVES

To determine the effects of tonsillectomy, with and without adenoidectomy, in patients with chronic/recurrent acute tonsillitis.

SEARCH STRATEGY

The Cochrane Ear, Nose and Throat Disorders Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, issue 2), MEDLINE (1966 to 2008), EMBASE (1974 to 2008), bibliographies, and additional sources were searched for published and unpublished trials. The date of the last search was 11 April 2008.

SELECTION CRITERIA

Randomised controlled trials comparing tonsillectomy, with or without adenoidectomy, with non-surgical treatment in adults and children with chronic/recurrent acute tonsillitis. We included trials which used reduction in the number and severity of tonsillitis and sore throat as main outcome measures.

DATA COLLECTION AND ANALYSIS

Two authors applied the inclusion/exclusion criteria independently.

MAIN RESULTS

This review includes five studies: four undertaken in children (719 participants) and one in adults (70 participants). Good information about the effects of tonsillectomy is only available for children and for effects in the first year following surgery.Children were divided into two subgroups: those who are severely affected (based on specific criteria which are often referred to as the 'Paradise criteria') and those less severely affected.For more severely affected children adeno-/tonsillectomy will avoid three unpredictable episodes of any type of sore throat, including one episode of moderate or severe sore throat in the next year. The cost of this is a predictable episode of pain in the immediate postoperative period.Less severely affected children may never have had another severe sore throat anyway and the chance of them so doing is modestly reduced by adeno-/tonsillectomy. For them, surgery will mean having an average of two rather than three unpredictable episodes of any type of sore throat. The cost of this reduction is one inevitable and predictable episode of postoperative pain. The 'average' patient will have 17 rather than 22 sore throat days but some of these 17 days (between five and seven) will be in the immediate postoperative period. Whilst the concept of the 'average' patient is attractive, in practice, wide variability is likely.One reason why the impact of surgery is so modest, is that many untreated patients get better spontaneously. There is a trade-off for the physician and patient who must weigh up a number of different uncertainties: what proportion of my throat symptoms are attributable to my tonsils, and will I get better without any treatment? Similarly, the potential 'benefit' of surgery must be weighed against the risks of the procedure.

AUTHORS' CONCLUSIONS: Adeno-/tonsillectomy is effective in reducing the number of episodes of sore throat and days with sore throats in children, the gain being more marked in those most severely affected. The size of the effect is modest, but there may be a benefit to knowing the precise timing of one episode of pain lasting several days - it occurs immediately after surgery as a direct consequence of it.It is clear that some children get better without any surgery, and that whilst removing the tonsils will always prevent 'tonsillitis', the impact of the procedure on 'sore throats' due to pharyngitis is much less predictable.

摘要

背景

扁桃体切除术,无论是否同时行腺样体切除术(腺样体/扁桃体切除术),都是常见的耳鼻喉科手术,但手术指征存在争议。

目的

确定扁桃体切除术(无论是否同时行腺样体切除术)对慢性/复发性急性扁桃体炎患者的影响。

检索策略

检索了Cochrane耳鼻喉疾病小组专业注册库、Cochrane对照试验中心注册库(CENTRAL)(《Cochrane图书馆》2008年第2期)、MEDLINE(1966年至2008年)、EMBASE(1974年至2008年)、参考文献以及其他来源,以查找已发表和未发表的试验。最后一次检索日期为2008年4月11日。

选择标准

比较扁桃体切除术(无论是否同时行腺样体切除术)与非手术治疗对慢性/复发性急性扁桃体炎成人和儿童影响的随机对照试验。我们纳入了以扁桃体炎发作次数和严重程度以及喉咙痛减轻作为主要结局指标的试验。

数据收集与分析

两位作者独立应用纳入/排除标准。

主要结果

本综述纳入了五项研究:四项针对儿童(719名参与者),一项针对成人(70名参与者)。关于扁桃体切除术效果的良好信息仅适用于儿童以及术后第一年的效果。儿童被分为两个亚组:受严重影响的儿童(基于通常称为“帕拉迪斯标准”的特定标准)和受影响较轻的儿童。对于受影响更严重的儿童,腺样体/扁桃体切除术可避免三次任何类型喉咙痛的不可预测发作,包括次年一次中度或重度喉咙痛发作。代价是术后短期内会有一次可预测的疼痛发作。受影响较轻的儿童无论如何可能再也不会有严重喉咙痛发作,腺样体/扁桃体切除术适度降低了他们出现这种情况的几率。对他们来说,手术意味着任何类型喉咙痛的不可预测发作平均为两次而非三次。这种减少的代价是一次不可避免且可预测的术后疼痛发作(。“平均”患者喉咙痛天数将从22天减至17天,但这17天中的一些天数(五至七天)将在术后短期内。虽然“平均”患者的概念很有吸引力,但实际上差异可能很大。手术影响如此适度的一个原因是,许多未经治疗的患者会自行好转。对于医生和患者来说,必须权衡许多不同的不确定性:我的喉咙症状有多大比例可归因于扁桃体,以及未经任何治疗我是否会好转?同样,手术的潜在“益处”必须与手术风险相权衡。

作者结论

腺样体/扁桃体切除术可有效减少儿童喉咙痛发作次数和喉咙痛天数,在受影响最严重的儿童中获益更为明显。效果大小适中,但知道一次持续数天的疼痛的确切时间可能有好处——它在手术后立即出现,是手术的直接后果。很明显,一些儿童未经任何手术也会好转,而且虽然切除扁桃体总能预防“扁桃体炎”,但该手术对因咽炎导致的“喉咙痛”的影响则更难预测。

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