Zhan Wenyan, Hu Jiameng, Chen Xiaoyun, Luo Gen, Song Xiaoxiao
College of Chemistry and Materials Science, Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Normal University, Wuhu, Anhui 241002, P. R. China.
Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Chem Commun (Camb). 2024 Dec 12;60(100):14984-14987. doi: 10.1039/d4cc04678a.
We present herein a highly efficient atroposelective synthesis of five/five-membered -indolizinylpyrrole through the chiral phosphoric acid (CPA) catalyzed Paal-Knorr reaction of 3-aminoindolizines and 1,4-diketones. The reaction features mild reaction conditions, broad substrate scope and excellent enantioselectivity. Moreover, this method provides a facile approach to a novel axially chiral indolizine-pyrrole framework.
我们在此展示了一种通过手性磷酸（CPA）催化3-氨基中氮茚与1,4-二酮的Paal-Knorr反应，高效地对映选择性合成五元/五元环中氮茚基吡咯的方法。该反应具有反应条件温和、底物范围广和对映选择性优异的特点。此外，该方法为一种新型的轴手性中氮茚-吡咯骨架提供了一种简便的合成途径。
