Bouda Maria, Hana Grace E, Xhili Dea, Sripada Archita, Bertke Jeffery A, Wolf Christian
Department of Chemistry, Georgetown University, Washington, D. C. 20057, USA.
Chem Commun (Camb). 2025 May 22;61(43):7883-7886. doi: 10.1039/d5cc01166c.
Organocatalytic atropisomeric synthesis with fluorinated oxindoles and 4-halo-3-nitrocoumarins gives congested structures displaying a Csp-Csp chirality axis and an adjacent tetrasubstituted stereogenic carbon center with good yields, up to 97% ee and 41 : 1 dr. The scalable dehalogenative C-C bond formation is achieved under mild conditions with a commercially available urea catalyst.
使用氟化氧化吲哚和4-卤代-3-硝基香豆素进行有机催化阻转异构合成，可得到具有拥挤结构的产物，这些产物具有Csp-Csp手性轴和相邻的四取代立体中心，产率良好，对映体过量高达97%，非对映体比例为41:1。使用市售的脲催化剂在温和条件下可实现可扩展的脱卤碳-碳键形成。
