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()波兰中部的多位点序列分型基因型。

() MLST Genotypes in Central Poland.

作者信息

Kuthan Robert

机构信息

Department of Medical Microbiology, Medical University of Warsaw, 5 Chałubińskiego Street, 02-004 Warsaw, Poland.

出版信息

Int J Mol Sci. 2025 May 6;26(9):4407. doi: 10.3390/ijms26094407.

Abstract

is a medically important fungal pathogen responsible for various opportunistic, life-threatening, and fatal infections, mainly among immunodepressed patients worldwide. Herein, genotypes identified in Central Poland by multilocus sequence typing (MLST) are presented. Along with the genotyping, drug susceptibility was performed. The research was conducted on 30 non-redundant clinical strains, and 15 distinct sequence types (STs) were identified, including three novel STs: ST212, ST213, and ST214. The most prevalent sequence types were ST3, ST6, and ST10. Antifungal susceptibility testing revealed varied resistance rates to azoles, with fluconazole susceptibility at 16.7% and high susceptibility to amphotericin B. No correlation between ST and antifungals MIC were found. The study findings highlight the genetic diversity of in Central Poland and the role of surveillance and research to elucidate antifungals resistance and molecular epidemiology of .

摘要

是一种具有医学重要性的真菌病原体,可导致各种机会性、危及生命和致命感染,主要发生在全球免疫抑制患者中。本文介绍了通过多位点序列分型(MLST)在波兰中部鉴定的基因型。除了基因分型外,还进行了药物敏感性测试。该研究对30株非冗余临床菌株进行,鉴定出15种不同的序列类型(STs),包括三种新的STs:ST212、ST213和ST214。最常见的序列类型是ST3、ST6和ST10。抗真菌药敏试验显示对唑类药物的耐药率各不相同,氟康唑敏感性为16.7%,对两性霉素B高度敏感。未发现ST与抗真菌药物MIC之间存在相关性。研究结果突出了波兰中部该菌的遗传多样性以及监测和研究在阐明该菌抗真菌耐药性和分子流行病学方面的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303f/12072302/2fbea2e891e7/ijms-26-04407-g001.jpg

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