Rao Xi, Chen Qianyun, Ding Lishan, Shahid Noman, Wafa Sidra, Huang Qiang, Qiu Enming, Zhang Xi, Wang Songsheng, Xia Xueer, Han Shuai, Chen Haijin, Li Zhou
Department of Gastrointestinal Surgery, General Surgery Center, Zhujiang Hospital, Southern Medical University, No. 253. Gongye Middle Avenue, Haizhu District, Guangzhou, Guangdong, 510280, China.
The Second School of Clinical Medicine, Southern Medical University, No.253. Gongye Middle Avenue, Haizhu District, Guangzhou, Guangdong, 510280, China.
Phys Eng Sci Med. 2025 Mar;48(1):75-85. doi: 10.1007/s13246-024-01490-1. Epub 2024 Nov 26.
A need exists for a quick, simple method to accurately assess resection margins and lymph node metastases in gastrointestinal cancer surgeries. We aimed to develop a real-time, non-destructive technique to differentiate between normal and cancerous tissues using dielectric properties. Dielectric properties of tissues from 50 gastric and 120 colorectal cancer patients were measured during surgery using an open-ended coaxial probe, spanning frequencies from 10 MHz to 4 GHz. Lymph nodes were classified based on pathology into metastatic and non-metastatic, and tissues were divided into cancerous and normal, the latter being 3 cm from the cancer edge. Statistically significant differences in dielectric properties were found between metastatic and non-metastatic lymph nodes (P < 0.05), and between normal and malignant tissues. Metastatic lymph nodes showed higher dielectric permittivity and conductivity across the frequency range, with no significant difference between gastric and colorectal cancers. The coaxial probe method distinguishes between metastatic and non-metastatic lymph nodes by their dielectric properties within 10-4000 MHz, offering a potential tool for real-time identification of malignant tissues during surgery, despite not identifying the cancer type.
在胃肠道癌手术中，需要一种快速、简单的方法来准确评估切缘和淋巴结转移情况。我们旨在开发一种实时、非破坏性技术，利用介电特性区分正常组织和癌组织。在手术过程中，使用开放式同轴探头测量了50例胃癌和120例结直肠癌患者组织的介电特性，频率范围为10 MHz至4 GHz。根据病理学将淋巴结分为转移性和非转移性，将组织分为癌组织和正常组织，后者距癌边缘3 cm。在转移性和非转移性淋巴结之间（P < 0.05）以及正常组织和恶性组织之间，发现介电特性存在统计学上的显著差异。在整个频率范围内，转移性淋巴结显示出更高的介电常数和电导率，胃癌和结直肠癌之间无显著差异。同轴探头法可通过10 - 4000 MHz范围内的介电特性区分转移性和非转移性淋巴结，尽管不能识别癌症类型，但为手术中实时识别恶性组织提供了一种潜在工具。
