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用于组织工程和药物递送系统的先进水凝胶作为生物材料的应用综述

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials.

作者信息

Choi Hoon, Choi Wan-Sun, Jeong Jin-Oh

机构信息

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Department of Orthopaedic Surgery, Ajou University School of Medicine, Suwon 16499, Republic of Korea.

出版信息

Gels. 2024 Oct 25;10(11):693. doi: 10.3390/gels10110693.


DOI:10.3390/gels10110693
PMID:39590049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11594258/
Abstract

Hydrogels are known for their high water retention capacity and biocompatibility and have become essential materials in tissue engineering and drug delivery systems. This review explores recent advancements in hydrogel technology, focusing on innovative types such as self-healing, tough, smart, and hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited for applications in dynamic biomedical environments. Tough hydrogels are designed with enhanced mechanical properties, enabling their use in load-bearing applications such as cartilage regeneration. Smart hydrogels respond to external stimuli, including changes in pH, temperature, and electromagnetic fields, making them ideal for controlled drug release tailored to specific medical needs. Hybrid hydrogels, made from both natural and synthetic polymers, combine bioactivity and mechanical resilience, which is particularly valuable in engineering complex tissues. Despite these innovations, challenges such as optimizing biocompatibility, adjusting degradation rates, and scaling up production remain. This review provides an in-depth analysis of these emerging hydrogel technologies, highlighting their transformative potential in both tissue engineering and drug delivery while outlining future directions for their development in biomedical applications.

摘要

水凝胶以其高保水能力和生物相容性而闻名,已成为组织工程和药物递送系统中的重要材料。本综述探讨了水凝胶技术的最新进展,重点关注自愈合、坚韧、智能和混合水凝胶等创新类型,每种类型都经过精心设计以克服传统水凝胶的局限性。自愈合水凝胶可以自主修复结构损伤,使其非常适合在动态生物医学环境中的应用。坚韧水凝胶具有增强的机械性能,可用于诸如软骨再生等承重应用。智能水凝胶对外部刺激作出反应,包括pH值、温度和电磁场的变化,使其成为针对特定医疗需求进行控释药物的理想选择。由天然和合成聚合物制成的混合水凝胶结合了生物活性和机械弹性,这在构建复杂组织方面特别有价值。尽管有这些创新,但仍存在诸如优化生物相容性、调整降解速率和扩大生产规模等挑战。本综述对这些新兴水凝胶技术进行了深入分析,强调了它们在组织工程和药物递送方面的变革潜力,同时概述了它们在生物医学应用中的未来发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e47/11594258/1277d718ef05/gels-10-00693-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e47/11594258/e318217047db/gels-10-00693-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e47/11594258/1277d718ef05/gels-10-00693-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e47/11594258/e318217047db/gels-10-00693-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e47/11594258/1277d718ef05/gels-10-00693-g002.jpg

相似文献

[1]
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials.

Gels. 2024-10-25

[2]
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[3]
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[4]
Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering.

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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Shape memory hydrogels in tissue engineering: Recent advances and challenges.

Bioact Mater. 2025-8-19

[2]
Advanced Hydrogels in Fibrocartilage Regeneration of the Glenoid Labrum.

Gels. 2025-8-18

[3]
Chitosan-Glycerol Injectable Hydrogel for Intratumoral Delivery of Macromolecules.

Gels. 2025-8-2

[4]
Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications.

Polymers (Basel). 2025-7-24

[5]
Sustainable Hydrogels for Medical Applications: Biotechnological Innovations Supporting One Health.

Gels. 2025-7-21

[6]
Bioactive Hydrogels for Spinal Cord Injury Repair: Emphasis on Gelatin and Its Derivatives.

Gels. 2025-6-26

[7]
Next-Generation Biomaterials for Load-Bearing Tissue Interfaces: Sensor-Integrated Scaffolds and Mechanoadaptive Constructs for Skeletal Regeneration.

J Funct Biomater. 2025-6-23

[8]
Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies.

J Transl Med. 2025-7-1

[9]
Cellulose-Based Hybrid Hydrogels for Tissue Engineering Applications: A Sustainable Approach.

Gels. 2025-6-6

[10]
Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics.

Gels. 2025-5-23

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